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Name: Beclomethasone Dipropionate

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Pregnancy Category C

Drug classes

• Corticosteroid
• Glucocorticoid
• Hormonal agent

Therapeutic actions

Anti-inflammatory effects; local administration into lower respiratory tract or nasal passages maximizes beneficial effects on these tissues while decreasing the likelihood of adverse corticosteroid effects from systemic absorption.

Indications

Respiratory inhalant use: Control of bronchial asthma that requires corticosteroids in conjunction with other therapy Intranasal use: Relief of symptoms of seasonal or perennial rhinitis that respond poorly to other treatments

Contraindications/cautions

Respiratory inhalant therapy: Acute asthmatic attack, status asthmaticus, systemic fungal infections (may cause excerbations), allergy to any ingredient, nursing a baby Intranasal therapy: Untreated local infections (may cause exacerbations); nasal septal ulcers, recurrent epistaxis, nasal surgery or trauma (interferes with healing); lactation

Adverse effects

• Respiratory Inhalant Use:
  • Endocrine: Cushing's syndrome with overdosage, suppression of hypothalamic-pituitary-adrenal (HPA) function due to systemic absorption
  • Local: Oral, laryngeal, pharyngeal irritation, fungal infections
• Intranasal Use
  • Respiratory: Epistaxis, rebound congestion, perforation of the nasal septum, anosmia
  • Local: Nasal irritation, fungal infections
  • Other: Headache, nausea, urticaria

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