Xolair reduced the rate of hospital emergency visits by 44% in patients with inadequately controlled asthma.
Amoline, Phyllocontin, Truphylline
Pregnancy Category C
Mechanism of action
Relaxes bronchial smooth muscle, causing bronchodilation and increasing vital capacity, which has been impaired by bronchospasm and air trapping; in higher concentrations, it also inhibits the release of slow-reacting substance of anaphylaxis (SRS-A) and histamine.
- Symptomatic relief or prevention of bronchial asthma and reversible bronchospasm associated with chronic bronchitis and emphysema
- Respiratory stimulant in Cheyne-Stokes respiration
- Treatment of apnea and bradycardia in premature babies
- Hypersensitivity to any xanthine or to ethylenediamine,
- Peptic ulcer
- Active gastritis
- Rectal or colonic irritation or infection (use of the rectal preparations)
Use caution in the presence of cardiac arrhythmias, acute myocardial injury, CHF, cor pulmonale, severe hypertension, severe hypoxemia, renal or hepatic disease, hyperthyroidism, alcoholism, labor, lactation.
- Serum theophylline levels 20-25 ?/ml: nausea, vomiting,
diarrhea, headache, insomnia, irritability (75% of patients)
- Serum theophylline levels 30-35 ?/ml: hyperglycemia, hypotension, cardiac arrhythmias, tachycardia ( 10 ?/ml in premature newborns); seizures, brain damage, death
- CNS: Irritability (especially children); restlessness, dizziness, muscle twitching, convulsions, severe depression, stammering speech; abnormal behavior characterized by withdrawal, mutism andunresponsiveness alternating with hyperactive periods
- GI: Loss of appetite, hematemesis, epigastric pain, gastroesophageal reflux during sleep, increased SGOT
- CV: Palpitations, sinus tachycardia,
ventricular tachycardia, life-threatening ventricular arrhythmias, circulatory
Respiratory: Tachypnea, respiratory arrest
- GU: Proteinuria, increased excretion of renal tubular cells & RBCs; diuresis (dehydration), urinary retention in men with prostate enlargement
- Other: Fever, flushing, hyperglycemia,
Are you a Doctor, Pharmacist, PA or a Nurse?
Join the Doctors Lounge online medical community
Editorial activities: Publish, peer review, edit online articles.
Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.