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Name: Glipizide

Pregnancy Category C

Drug classes

  • Antidiabetic agent
  • Sulfonylurea, second generation

Therapeutic actions

Stimulates insulin release from functioning beta cells in the pancreas; may improve binding between insulin and insulin receptors or increase the number of insulin receptors; more potent in effect than first-generation sulfonylureas.


Adjunct to diet to lower blood glucose in patients with non-insulin-dependent diabetes mellitus (Type II) Adjunct to insulin therapy in the stabilization of certain cases of insulin-dependent maturity-onset diabetes, reducing the insulin requirement and decreasing the chance of hypoglycemic reactions


Allergy to sulfonylureas; diabetes complicated by fever, severe infections, severe trauma, major surgery, ketosis, acidosis, coma (insulin is indicated in these conditions); Type I or juvenile diabetes, serious hepatic impairment, serious renal impairment, uremia, thyroid or endocrine impairment, glycosuria, hyperglycemia associated with primary renal disease; labor and delivery (if glipizide is used during pregnancy, discontinue drug at least 1 mo before delivery); lactation.

Adverse effects

  • GI: Anorexia, nausea, vomiting, epigastric discomfort, heartburn, diarrhea
  • CV: Increased risk of cardiovascular mortality
  • Hematologic: Leukopenia, thrombocytopenia, anemia
  • Hypersensitivity: Allergic skin reactions, eczema, pruritus, erythema, urticaria, photosensitivity, fever, eosinophilia, jaundice
  • Endocrine: Hypoglycemia

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