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Date of last update: 10/17/2017.

Forum Name: Endocrinology Topics

Question: Aldosterone, potassium, spironolactone question


 skimom - Wed May 30, 2007 10:13 pm

Can spironolactone increase potassium levels in someone who has normal adrenal glands In other words, if spironolactone corrects a low potassium problem, is that a guarantee that an adrenal problem is present?

If aldosterone and renin levels are tested (blood and urine) when a person is taking spironolactone, would the results be accurate?

This is a great web site! Thanks in advance!
 Dr. Chan Lowe - Fri Jul 06, 2007 2:25 am

User avatar Spironolactone can increase potassium levels in normal individuals as well. This occurrence does not mean there is a problem with the adrenal glands.

The renin and aldosterone levels may or may not be affected by the spironolactone. I would tend to think that the aldosterone levels, in particular, would be affected because spironolactone can cause electrolyte variations that aldosterone responds to. Unfortunately I am not knowledgeable enough about this to answer this part of your question definitively.

Best wishes.

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