Medical Specialty >> Endocrinology

Doctors Lounge - Endocrinology Answers

Back to Endocrinology Answers List

If you think you may have a medical emergency, call your doctor or 911 immediately. Doctors Lounge ( does not recommend or endorse any specific tests, physicians, products, procedures, opinions, or other information that may be mentioned on the Site.

DISCLAIMER: The information provided on is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Please read our 'Terms and Conditions of Use' carefully before using this site.

Date of last update: 10/17/2017.

Forum Name: Endocrinology Topics

Question: Aldosterone, potassium, spironolactone question

 skimom - Wed May 30, 2007 10:13 pm

Can spironolactone increase potassium levels in someone who has normal adrenal glands In other words, if spironolactone corrects a low potassium problem, is that a guarantee that an adrenal problem is present?

If aldosterone and renin levels are tested (blood and urine) when a person is taking spironolactone, would the results be accurate?

This is a great web site! Thanks in advance!
 Dr. Chan Lowe - Fri Jul 06, 2007 2:25 am

User avatar Spironolactone can increase potassium levels in normal individuals as well. This occurrence does not mean there is a problem with the adrenal glands.

The renin and aldosterone levels may or may not be affected by the spironolactone. I would tend to think that the aldosterone levels, in particular, would be affected because spironolactone can cause electrolyte variations that aldosterone responds to. Unfortunately I am not knowledgeable enough about this to answer this part of your question definitively.

Best wishes.

| Check a doctor's response to similar questions

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us