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Date of last update: 10/17/2017.

Forum Name: Endocrinology Topics

Question: Can Spironolactone cause gum/mouth problems?

 caligirl072007 - Sun Sep 16, 2007 10:03 pm

I am a 25 year old female who has been diagnosed on again and off again with PCOS for the past five years. I display classic symptoms: irregular periods, obesity, thinning hair, and acne. My last doctor put me on a regimen of Spironolactone and Loestrin 24 Fe to counteract these side effects, and I have been taking these medications for the past two months. I have also lost nearly 30 pounds during this time due to a concerted weight loss effort.

For the past two days I have been suffering from painful, swollen, extremely tender gums. I also have a metallic taste in my mouth. Could these problems be a side effect of my medication? I researched my problems online, and it appears like extra testosterone causes these kinds of problems. And though I do have high testosterone, I thought that's what the anti-androgen was supposed to balance...? So now I'm confused. I don't think I have gum disease because I've always had remarkably healthy teeth and gums. What gives?
 Dr. Chan Lowe - Sun Sep 16, 2007 10:27 pm

User avatar Hi Caligirl072007,

I checked the side effect profile of spironolactone. These effects are not common side effects. However, the way you describe the onset of these issues is very suspicious for a drug effect.

I would recommend you see your doctor about this soon.

Best wishes.

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