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Date of last update: 10/17/2017.

Forum Name: Diabetes

Question: insulin rsistance and very lean

 veka82 - Wed Apr 29, 2009 12:35 pm

I'm a 26 year old female and i have receantly been diagnosed with Insulin Resistance. I went to doctor because my periods were mildly irregular and i was suffering from hirtuism.i also feel tired all the time. My fasting blood glucose levels and fasting insulin levels are in normal range, but my OGTT showed Insulin Resistance. All my other labs were normal. ( those include liver panel, minerlas, lipid profile, IgG, IgA, IgM, CRP, CEA, AFP, CA15, CA125, CA19, FSH, LH, E2, Progesteron, PRL, Testosteron, andostendion, HGH, ACTH, cortisol, 17-KS, 17-OHS). Only DHEA is elevated (17nmol/L).
I am normal weight, more like somewhat skinny. My BMI is 19.5. So what makes no sence to me is: Insulin Resistance is always linked to overweight people....
I was perscribed Metformin 500mg 2x a day. I am very concerned that the Metformin is going to make me loose even more weight. Is that a possibility?
I have not started taking the medication because of this concern yet.
thank you for answering my questions nad please excuse a ny possibe spelling errors as my english is not perfect
thak you
 Dr.M.jagesh kamath - Mon Sep 06, 2010 12:03 pm

User avatar Hello,Insulin resistance has been found in PCOS both in the obese and lean.There is also compelling evidence that metformin increased insulin sensitivity,obviously in the obese but even in the lean as well.Thus metformin has been considered as an integral part of therapy even in the lean PCOS patients.The drug also reduces clinical manifestations of hyperandrogenism in these patients.
Best wishes.

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