Name: Magnesium Hydroxide
Pregnancy Category C
Mechanisms of action
- Antacid (magnesium hydroxide, magnesium oxide): neutralizes or reduces gastric acidity, resulting in an increase in the pH of the stomach and duodenal bulb and inhibition of the proteolytic activity of pepsin.
- Laxative (magnesium citrate, magnesium hydroxide): attracts/retains water in intestinal lumen and distends bowel; causes the duodenal secretion of cholecystokinin, which stimulates fluid secretion and intestinal motility.
- Symptomatic relief of upset stomach associated with hyperacidity
- Hyperacidity associated with peptic ulcer, gastritis, peptic esophagitis, gastric hyperacidity, and hiatal hernia
- Prophylaxis of GI bleeding, stress ulcers, aspiration pneumonia
- Short-term relief of constipation; evacuation of the colon for rectal and bowel examination
- Contraindicated in the presence of allergy to magnesium products.
- Use caution in the presence of renal insufficiency.
- CNS: Dizziness, fainting, sweating
- GI: Diarrhea, nausea, perianal irritation
- Metabolic: Hypermagnesemia and toxicity in renal failure patients
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