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Name: Sucralfate

Pregnancy Category B

Drug classes

  • Antipeptic agent

Therapeutic actions

Forms an ulcer-adherent complex at duodenal ulcer sites, protecting the ulcer against acid, pepsin, and bile salts, thereby promoting ulcer healing; also inhibits pepsin activity in gastric juices.

Indications

Short-term treatment of duodenal ulcers, up to 8 wk Maintenance therapy for duodenal ulcer patients at reduced dosage after healing has occurred

Unlabeled uses: accelerates healing of gastric ulcers, treatment of NSAID- or aspirin-induced GI symptoms and GI damage, prevention of stress ulcers in critically ill patients

Orphan drug use: treatment of oral and esophageal ulcers due to radiation, chemotherapy, and sclerotherapy

Contraindications/cautions

Allergy to sucralfate, chronic renal failure/dialysis (buildup of aluminum may occur if taken in conjunction with aluminum-containing products), pregnancy, lactation.

Adverse effects

  • CNS: Dizziness, sleeplessness, vertigo
  • GI: Constipation, diarrhea, nausea, indigestion, gastric discomfort, dry mouth
  • Dermatologic: Rash, pruritus
  • Other: Back pain

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