Back to GIT prokinetic drugs
Brand Name: Propulsid
Name: Cisapride
IMPORTANT NOTE: WITHDRAWAL FROM US MARKET. PROPULSID IS AVAILABLE IN THE U.S. VIA LIMITED ACCESS PROTOCOL ONLY.
Pregnancy Category C
Drug classes
- Prokinetic agent
- GI drug
Therapeutic actions
Increases the release of acetylcholine in the myenteric plexus; thus, improves GI motility with little to no dopaminergic action.
Indications
Symptomatic treatment of nocturnal heartburn due to gastroesophageal reflux disease
Contraindications/cautions
Allergy to Propulsid, gallbladder disease, GI hemorrhage, GI obstruction, pregnancy, lactation, prolonged Q-T interval.
Adverse effects
- CNS: Headache, fatigue, somnolence
- GI: Abdominal pain, diarrhea, constipation, nausea, vomiting, borborygamus, bloating
- CV: Serious cardiac arrhythmiaswhen used in combination drug regimens
- Respiratory: Rhinitis, sinusitis, cough-ing, upper respiratory infections
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