Medical Specialty >> Gastroenterology

Doctors Lounge - Gastroenterology Answers

Back to Gastroenterology Answers List

If you think you may have a medical emergency, call your doctor or 911 immediately. Doctors Lounge ( does not recommend or endorse any specific tests, physicians, products, procedures, opinions, or other information that may be mentioned on the Site.

DISCLAIMER: The information provided on is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Please read our 'Terms and Conditions of Use' carefully before using this site.

Date of last update: 10/15/2017.

Forum Name: Gastroenterology Topics

Question: High Platelet Count/Celiac Disease

 plantation - Sat Jul 07, 2007 5:47 pm

I was diagnosed with Celiac Disease 3 years ago. I am following my gluten free diet. My platelet count has been inching up and is now at 500,000. My hematologist mentioned that this may be connected to Celiac Disease, but my SED rate test showed no inflammation. I'm returning in a month for a retest. Is it possible to have increasing platelet count due to Celiac Disease?

 Dr. Chan Lowe - Sun Jul 08, 2007 10:25 pm

User avatar Platelets are considered to be an acute phase reactant meaning that they can become elevated in response to inflammation.

The ESR (sed rate) is a similar marker of inflammation. The ESR rises slowly so it is possible that you may be in the early stages of a celiac flare and the ESR has simply not responded yet. There is another test called c-reactive protein (CRP) that responds much faster to inflammation.

If there is concern about some inflammatory state going on, checking the CRP would be helpful.

Keep in mind also that any source of inflammation can cause the platelets to increase not just celiac disease so they may be increasing for a different reason.

Best wishes.

| Check a doctor's response to similar questions

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us