Doctors Lounge - Gastroenterology Answers
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Forum Name: Gastroenterology Topics
Question: Interpreting celiac panel results
|borst - Sun Nov 11, 2007 11:49 pm|
Hi, new member here.
I've been trying to tackle my health issues for about 4 years now with no definitive answer. This is my history that i typed up for my new physician that i'm seeing (trying to seek a second opinion). I tried to make it as concise as possible but i have a complicated history.
Anyway, the first thing my new physician wanted to do was run some general bloodwork as well as a celiac panel. I got the results back today:
So my Glidin IgA is positive, my Gliadin IgG borderline, and my Transglutaminase IgA looks negative.
My doctor said I may have a gluten sensitivity but not "full blown Celiac". What do you guys think?
The rest of my bloodwork showed some spikes as well..
The bloodwork also included a random glucose test, calcium, vitamin b12, Ferriton, sTSH, T4 Free, Free T3, GGT, AST, Alkaline Phosphatase, all came back within normal range.
I'm getting a referral back to the same gastroenterologist that i had before, hopefully will get some more answers this time
Any advice/suggestions/insight would be appreciated.
|Dr. Chan Lowe - Tue Nov 13, 2007 10:57 pm|
The antibody panel for celiac disease only provides supporting or contrary evidence for the disease. It generally should not be used to make the diagnosis. If, however, you have all the symptoms and have positive antibodies it makes the disease much more likely. Formal diagnosis is best made by doing an endoscopy and biopsying the small intestine to see if it looks inflamed and consistent with celiac disease.
Your symptoms may be consistent with celiac disease. They may also be consistent with irritable bowel disease. It may be worth a trial of a gluten free diet to see if your symptoms get better. If they do this would support celiac disease also. I would recommend that you follow up with a GI specialist for further evaluation of this.
|borst - Wed Nov 14, 2007 1:23 pm|
Thank you Doctor
I assume when you say Irritable Bowel Disease, you mean Inflammatory Bowel Disease? Are there usually differential symptoms between Celiac and IBD?
Also I was also concerned about kidney function.
My Creatinine level was 111 μmol/l which was one unit over the reference high range of 110 which gave me an eGFR of 76. Also my elevated electrolyte levels (sodium potassium) and magnesium, although only slightly above normal were of concern. My doctor mentioned these could have been just from me being slightly dehydrated at the time.
Any insight would be appreciated.
|Dr. Chan Lowe - Thu Nov 15, 2007 1:09 am|
Celiac disease and inflammatory bowel disease are two distinct issues. Inflammatory bowel disease includes both ulcerative colitis and Crohn's disease. All three are antibody mediated diseases, though.
In my previous post I was actually thinking more of irritable bowel syndrome (IBS). I mistakenly referred to this as irritable bowel disease, a name by which it really isn't known. Sorry for any confusion.
The creatinine issue may very well have been due to some mild dehydration. It may also simply have been a normal value that had some variation based on the lab technique. Being one point over the upper limits is still basically normal.
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