Eosinophilia is the state of having high eosinophil granulocytes in the blood. Normal ranges are between 0 and 0.5 109 per litre of blood. Eosinophilia is presence of more than 450 cells/microL in blood.
The release of interleukin-5 by T cells, mast cells and macrophages stimulates the production of eosinophils.
Diseases that feature eosinophilia: They can be easily be remembered by the famous mnemonic "CHINA".
- C - Connective tissue diseases
- H - Helminthic (ie, worm) infections
- I - Idiopathic HES
- N - Neoplasia
- A - Allergies
Connective tissue disease
- Eosinophilia-myalgia syndrome (due to tryptophan in the United States in 1989)
- Rheumatoid arthritis
- Toxic-oil syndrome (due to contaminated rapeseed oil in Spain in 1981)
- Churg-Strauss vasculitis
- Coccidioidomycosis fungal infection
- Eosinophilic fasciitis
- Visceral larva migrans
Idiopathic hypereosinophilic syndrome
- Lymphoma (e.g. Hodgkin lymphoma, non-Hodgkin lymphoma)
- Adult T-cell leukemia/lymphoma (ATLL)
- Human T-cell lymphotropic virus I (HTLV-I)
- Gastric or lung carcinoma (i.e. paraneoplastic eosinophilia)
- Eosinophilic leukemia (very rare)
- Allergic rhinitis
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