Pernicious anemia

(Addisonian anemia)

Autoimmune disorder in which antibodies attack the gastric mucosa (causing gastric atrophy) or intrinsic factor. This leads to inadequate absorption of intrinsic factor and hence a decrease in vitamin B12 absorption (macrocytic anemia).

There is an association with other autoimmune diseases: vitiligo, Addison's disease, thyroid diseases.

Clinical suspicion

macrocytic anemia due to B12 deficiency.


Schilling test


previous.gif (72x17 -- 347 bytes) next.gif (72x17 -- 277 bytes)

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us