Heparin calcium injection
heparin sodium injection
Lipo-Hepin, Liquaemin Sodium
heparin sodium and 0.9% sodium chloride, heparin sodium lock flush solution
Heparin Lock Flush, Hep-Lock
Pregnancy Category C
Mechanism of action
Inhibits thrombus and clot formation by blocking the conversion of prothrombin to thrombin and fibrinogen to fibrin, the final steps in the clotting process.
- Prevention and treatment of venous thrombosis and pulmonary embolism
- Treatment of atrial fibrillation with embolization
- Diagnosis and treatment of disseminated intravascular coagulation
- Prevention of clotting in blood samples and heparin lock sets and during dialysis procedures
Unlabeled uses: adjunct in therapy of coronary occlusion with acute MI, prevention of left ventricular thrombi and CVA post-MI, prevention of cerebral thrombosis in the evolving stroke
- Hypersensitivity to heparin
- Severe thrombocytopenia
- Uncontrolled bleeding
- Any patient who cannot be monitored regularly with blood coagulation tests
- Labor and immediate postpartum period
- Women older than 60 y are at high risk for hemorrhaging
- Recent surgery or injury
- Hematologic: Hemorrhage; bruising; thrombocytopenia; elevated SGOT, SGPT levels, hyperkalemia
- Dermatologic: Loss of hair
- Hypersensitivity: Chills, fever, urticaria, asthma
- Other: Osteoporosis, suppression of renal function (long-term, high-dose therapy)
Treatment of overdose
Protamine sulfate (1% solution). Each mg of protamine neutralizes 100 USP heparin U. Give very slowly IV over 10 min, not to exceed 50 mg. Establish dose based on blood coagulation studies
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