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Back to Unfractionated Heparin

Heparin calcium injection

heparin sodium injection
Lipo-Hepin, Liquaemin Sodium
heparin sodium and 0.9% sodium chloride, heparin sodium lock flush solution
Heparin Lock Flush, Hep-Lock

Pregnancy Category C

Drug classes

Unfractionated heparin

Mechanism of action

Inhibits thrombus and clot formation by blocking the conversion of prothrombin to thrombin and fibrinogen to fibrin, the final steps in the clotting process.


  1. Prevention and treatment of venous thrombosis and pulmonary embolism
  2. Treatment of atrial fibrillation with embolization
  3. Diagnosis and treatment of disseminated intravascular coagulation
  4. Prevention of clotting in blood samples and heparin lock sets and during dialysis procedures

Unlabeled uses: adjunct in therapy of coronary occlusion with acute MI, prevention of left ventricular thrombi and CVA post-MI, prevention of cerebral thrombosis in the evolving stroke


  1. Hypersensitivity to heparin
  2. Severe thrombocytopenia
  3. Uncontrolled bleeding
  4. Any patient who cannot be monitored regularly with blood coagulation tests
  5. Labor and immediate postpartum period
  6. Women older than 60 y are at high risk for hemorrhaging
  7. Dysbetalipoproteinemia
  8. Recent surgery or injury

Adverse effects

  • Hematologic: Hemorrhage; bruising; thrombocytopenia; elevated SGOT, SGPT levels, hyperkalemia
  • Dermatologic: Loss of hair
  • Hypersensitivity: Chills, fever, urticaria, asthma
  • Other: Osteoporosis, suppression of renal function (long-term, high-dose therapy)

Treatment of overdose

Protamine sulfate (1% solution). Each mg of protamine neutralizes 100 USP heparin U. Give very slowly IV over 10 min, not to exceed 50 mg. Establish dose based on blood coagulation studies

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