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Date of last update: 10/12/2017.

Forum Name: Hematology Topics

Question: Low CD4 count, negative HIV

 tdom - Tue Nov 29, 2005 10:15 pm

41 y/o female with low CD4 of 450 (NL=600-1200) and negative HIV. I have been experiencing monthly vaginal yeast infections and recurrent sinusitis for last year. Always healthy before now. WBC=3.4 (low). platelets=468K (hi) Also have hypothyroid and high chol (taking meds)
 Dr. Safaa Mahmoud - Sun Jul 16, 2006 8:22 pm

User avatar Dear tdom,

CD4/CD8 Ratio is an indicator for the competence of the immune system.

Low percentage of CD4 cells is known to all of us as a feature of HIV infection in which there is also reduced CD4/CD8 ratios, reduced lymphocyte function, lymphoid organs atrophy, and suppression of cell-mediated immunity.

CD4 cells count decrease also in many other conditions like:
Bacterial infections like Pneumonia, pyelonephritis, abscesses, infected wounds, cellulitis, TB, and sepsis
Parasitic infections
Nearly all viruses interfere with lymphocyte function
In mononucleosis
It can be caused by injuries and burns
After overexercising
Low CD4 counts in malnutrition
Hemophilia and
Psychological stress

worth noting that,
Free thyroxin level and CD4 cell counts are found to be correlated: in conditions associated with low free thyroxin the number of circulating CD4 was found to be low.

I advise you to check for the serum level of your thyroid hormones and to follow up with your doctor and to update him with any new symptoms.

Best regards,

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