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Date of last update: 10/12/2017.

Forum Name: Hematology Topics

Question: albumin/globulin ratio

 yahoo - Sat Dec 10, 2005 5:01 pm

My globulin level is 4.2 and my albumin/globulin ratio is 0.8, which is considered to be low. I bruise easily. I also have ulcerative colitis and enteropathic arthritis. I take about 3 to 4 tramadol a day for pain management. Why is my A/G ration low?
 Dr. Safaa Mahmoud - Sun Jul 16, 2006 7:53 pm

User avatar Dear yahoo,

The normal serum ablumin range is 3.4 to 5.4 g/dL.

Absolute increase in serum albumin content is only seen after infusion of hyperoncotic albumin suspensions.

Relative increase is seen in cases of in hemoconcentration.

Decreased serum albumin is due to many causes which include:
-Decreased synthesis in malnutrition, malabsorption, liver disease, and other chronic diseases.
- Increased loss in nephrotic syndrome, many GI conditions, thermal burns, etc.
- Increased catabolism in thyrotoxicosis, cancer chemotherapy, Cushing's disease, familial hypoproteinemia.

Globulin is increased disproportionately to albumin resulting in decreasing the albumin/globulin ratio in disorders due to :
- Chronic inflammation Like inflammatory bowel diseases e.g. Ulcerative colitis.
- B-lymphocyte neoplasms such as myeloma and Waldenstrom's macroglobulinemia.

Decreased globulin may be seen in congenital or acquired hypogammaglobulinemic states.

I hope these informations are helpful.

I advise you to follow up with your doctor and to update him with any new symptoms.

Best regards,

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