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Date of last update: 10/12/2017.

Forum Name: Hematology Topics

Question: Giant platelets, High RDW, Low Platelets

 tarheelluv1 - Tue Mar 31, 2009 5:44 pm

Hi. I went to see a weight loss doctor who did a complete blood work up on me. Other than being 35 pounds overweight, I am in excellent health. I am a 40 year old female. He said I had some issues with my platelets. The lab had even typed "GIANT PLATELETS" in bold uppper caps letters on my lab reports. Here are the numbers from my CBC and Differentials:

WBC 5.7
RBC 4.71
HGB 13.4
HCT 40.9
MCV 86.8
MCH 28.3
RDW 15.1 High
Platelet 130 Low
Then they typed in "GIANT PLATELETS" on the lab report

Neutrophils 70.6
Lymph 19.1 Low
Monocytes 8.8
Eosinophils 1.0
Basophils 0.5
Absolute Neut 4.00
Absolute Lymph 1.10 low
Absolute Mono 0.50
Absolute EOS 0.10
Absolute BASOS 0.00

Does anyone know what this might mean? I will tell you that my father, sister, and multiple first cousins have been diagnosed with ITP. I had an uncle die of leukemia, and an uncle die of lymphoma. Any ideas? Thanks in advance.
 Dr.M.jagesh kamath - Fri Aug 27, 2010 6:03 am

User avatar Hello,Giant platelets can occur as congenital or acquired.The congenital form May-hegglin anomaly has giant platelets,inclusion bodies in neutrophils and thrombocytopenia(Low platelets).Clinically they show only mild symptoms or no symptoms.But cases of severe post operative bleeding has been reported.Otherwise platelets are normal functionally. Pathogenesis is unknown.No specific treatment is known.Acquired can be a part of myelodysplasias.
Do get an hematological evaluation.Best wishes.

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