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Date of last update: 10/12/2017.

Forum Name: Hematology Topics

Question: What are implications of Low Neutrophils /High IgM?

 AJ63 - Sun May 03, 2009 5:31 pm

hi everyone:
I have had some confusing lab results, and I'm hoping you can help me understand them. My doctor was checking to see if I had Anti Phospohlid Syndrome. I'm healthy, non-smoker, don't drink any alcohol, 18.6 BMI, very fit, 46 year old female. Only other DX of importance could be Long QT, but I don't know if that's relevant.

The result is listed first, with the lab reference range in parentheses.

Neutrophils (absolute count): 1.4 (2.1-6.5)
Eosinophils 6 (0-4%)
Lymphocytes 41 (13-46%)
Monos 10 (4-12%)
Neutrophils % 43 (41-81)

WBC (K/ul) 3.3 (3.5-12.5)
Hematocrit, Hgb, MCV, Platelets, RDW, RBC all normal

Cardiolipin IgM >100 (1-9 Mpl) (was 41 in 08; no gammopathy back then. I don't know about now yet)
INR PT 11.2 (9.1-11.2 sec)
Beta 2 Glycoprotein ser/plas U/ml
[list=]IGA <10
IGG <20
IGM 14[/list]

CRP, homocysteine, and cardiolipin IGG all normal.
Cryoglobulins negative
Lupus Anticoagulant, ANA all negative (although I had an ANA of 1:640 speckled in 2004--negative since then).

a) Is there any relationship between the IgM and the low neutrophils?

b) My doctor wants to test again in 3 months. If you were my doctor, what would be the lab tests you would run at that time? Would you test for beta 2 microglobulins?

c) What are the implications of having high cardiolipins alone (that is, if the other tests listed above are essentially normal)?

d) If a doctor asks me if I have a clotting problem, and I've had no clinical signs of a clotting problem, based on the results listed above, do I say yes or no or kind of?

Thanks for your help.

 AJ63 - Mon Jun 01, 2009 6:03 pm

The results also show no gammopathy, which is good, I think.

Thanks for your advice when you get to me


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