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Date of last update: 10/12/2017.

Forum Name: Hematology Topics

Question: Factor XII Deficiency and miscarriage

 PMarie - Wed May 18, 2005 12:07 pm

I recently got pregnant after having endometriosis surgery. I miscarried at 10 weeks. Because it was my third miscarriage, my doctor ran a battery of tests. My ptt came back elevated and I was refered to a hematologist. I was diagnosed with Factor XII deficiency. I will be speaking with a fertility specialist in several weeks. In the meantime, I am searching for information about Factor XII deficiency and recurrent miscarriages. One article I read indicates there is a connection. Everything else I have read is vague. Can you give me any information on this topic. I would like to know if the miscarriages are related to my clotting problem. Thanks!
 Dr. Tamer Fouad - Sun Jan 29, 2006 8:16 am

User avatar Hello,

First, I hope it all went well for you.

Defects involving Hageman factor (factor XII) can cause laboratory abnormalities but no clinical bleeding.

Despite the often dramatic prolongation of the PTT deficient individuals have normal hemostasis and should neither be treated inappropriately with plasma nor denied indicated surgery on the basis of these laboratory abnormalities.

That said however, I have also read one particular study that was conducted in Germany. The authors asserted a relation between recurrent spontaneous abortions and factor XII defeciency.[1]

At any rate you would need to be monitored by both your gynecologist and your hematologist during your pregnancy. At the same time you need to exclude other causes that may lead to recurrent abortion.

Best regards.

1. Pauer HU, et al. Factor XII deficiency is strongly associated with primary recurrent abortions. Fertil Steril. 2003 Sep;80(3):590-4.

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