Bert Vogelstein, MD
Bert Vogelstein, MD

Medical Doctor

Medical Specialty


Cancer genetics and its clinical implications

Bert Vogelstein, M.D. was the first scientist to elucidate the molecular basis of a common human cancer. In particular, he and his colleagues have demonstrated that colorectal tumors result from the gradual accumulation of genetic alterations in specific oncogenes and tumor suppressor genes. His group’s discovery and analysis of these genes and their functions represent a landmark in the application of molecular biology to the study of human disease. His work on colorectal cancers forms the paradigm for much of modern cancer research, with profound implications for diagnostic and therapeutic strategies in the future. More recently, Vogelstein and his colleagues were the first to map cancer genomes and use personalized genomic sequencing to identify the genetic culprit to a hereditary cancer.

Vogelstein was elected to the American Academy of Arts and Sciences and the National Academy of Sciences in 1992, and to the American Philosophical Society in 1995. He became a fellow of the American Association for the Advancement of Science in 2006. His advisory roles have included chairmanship of the National Research Council Committee on the Biological and Biomedical Applications of Stem Cell Research and the Board of Scientific Counselors of the National Human Genome Research Institute. He has also held editorial positions at Science, Molecular Cell, Cancer Cell and The New England Journal of Medicine.

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