Create Account | Sign In: Author or Forum

Search Symptoms

Category: Internal Medicine | Ophthalmology | Pharmacy | Urology | Journal

Back to Journal Articles

Erectile Dysfunction Meds Tied to Higher Risk for Vision Issues

Last Updated: April 11, 2022.

Eyesight control

MONDAY, April 11, 2022 (HealthDay News) -- Regular users of phosphodiesterase type 5 inhibitors (PDE5Is) for erectile dysfunction may have an increased risk for adverse ocular events, according to a study published online April 7 in JAMA Ophthalmology.

Mahyar Etminan, Pharm.D., from the University of British Columbia in Vancouver, Canada, and colleagues quantified the risk for serous retinal detachment (SRD), retinal vascular occlusion (RVO), and ischemic optic neuropathy (ION) associated with the use of PDE5Is. The analysis included data from 213,033 men receiving PDE5Is (sildenafil, tadalafil, vardenafil, and avanafil) from 2006 through 2020, while the case-control analysis included a total of 1,146 cases of SRD (278), RVO (628), and ION (240) and 4,584 controls.

The researchers found that patients with SRD, RVO, and ION were more likely to have hypertension, diabetes, coronary artery disease, and sleep apnea. For the composite of any of the three outcomes, the incidence rate ratio (IRR) was 1.85 (incidence, 15.5 cases per 10,000 person-years). For the three individual outcomes, the adjusted IRR was 2.58 (incidence, 3.8 cases per 10,000 person-years) for SRD, 1.44 (incidence, 8.5 cases per 10,000 person-years) for RVO, and 2.02 (incidence, 3.2 cases per 10,000 person-years) for ION.

"Regular users of PDE5Is need to be cognizant of ocular adverse events associated with these drugs and alert their physicians if they experience any visual deficits," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)


Previous: COVID-19 Vaccine Largely Protects Cancer Patients Next: Prostate Cancer Biopsy, Diagnoses Down During the Pandemic

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion: