Create Account | Sign In: Author or Forum

Search Symptoms

Category: Cardiology | Family Medicine | Internal Medicine | Critical Care | Oncology | Pulmonology | Conference News

Back to Journal Articles

ATS: Meta-Analysis Confirms Statins’ Anti-Thrombotic Effect

Last Updated: May 18, 2010.

The preponderance of evidence shows that statins do decrease the risk of venous thromboembolism, according to research presented May 16 at the annual international conference of the American Thoracic Society, held in New Orleans May 14-19, and published in the May issue of American Journal of Respiratory and Critical Care Medicine.

TUESDAY, May 18 (HealthDay News) -- The preponderance of evidence shows that statins do decrease the risk of venous thromboembolism, according to research presented May 16 at the annual international conference of the American Thoracic Society, held in New Orleans May 14-19, and published in the May issue of American Journal of Respiratory and Critical Care Medicine.

V. Agarwal, of the University of Connecticut Health Center, Hartford, and colleagues conducted a meta-analysis of 10 studies that evaluated the effect of statin drugs on deep vein thrombosis (DVT), pulmonary embolism (PE) or any venous thromboembolism (VTE), defined as DVT and/or PE. Only one randomized trial, JUPITER, met the inclusion criteria.

In JUPITER, the adjusted odds ratio (AOR) for VTE was 0.57; the AORs for DVT only and PE only were 0.45 and 0.77, respectively. Observational studies showed less risk reduction for VTE and DVT, but a larger risk reduction for PE. For all studies combined, the effect of statins was a 32 percent risk reduction for VTE, a 41 percent risk reduction for DVT only, and a 30 percent risk reduction for PE only.

"The totality of clinical study evidence suggests that statins can reduce patients' odds of developing DVT or PE," the authors write.

Full Text (subscription or payment may be required)
More information


Previous: Major Depression Prevalent After Traumatic Brain Injury Next: ACOG: Flibanserin Effective for Sexual Desire Disorder

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion: