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Impaired Kidney Function Linked to Future Stroke Risk

Last Updated: October 01, 2010.

A low estimated glomerular filtration rate is associated with later risk of stroke, and even early stages of chronic kidney disease are associated with a higher risk of subsequent coronary heart disease, according to research published Sept. 30 in BMJ.

FRIDAY, Oct. 1 (HealthDay News) -- A low estimated glomerular filtration rate (eGFR) is associated with later risk of stroke, and even early stages of chronic kidney disease are associated with a higher risk of subsequent coronary heart disease, according to research published Sept. 30 in BMJ.

Meng Lee, M.D., of the University of California in Los Angeles, and colleagues analyzed data from 21 articles that estimated GFR at baseline and assessed incident stroke. They found that stroke risk was higher in individuals with an eGFR below 60 ml/min/1.73 m² (relative risk, 1.43), but not in those with an eGFR of 60 to 90. Asians with a low eGFR were at higher risk of stroke than non-Asians.

Emanuele Di Angelantonio, M.D., of the University of Cambridge in the United Kingdom, and colleagues analyzed data from 16,958 individuals aged 33 to 81 who didn't have evident vascular disease; 7 percent had chronic kidney disease at entry. Among those with chronic kidney disease, hazard ratios for coronary heart disease ranged from 1.55 for stage 1 to 4.29 for stage 4.

"Once chronic kidney disease is identified in a patient at high risk of cardiovascular disease, what interventions are needed?" write the authors of an accompanying editorial. "In the absence of clear evidence that a different approach is appropriate, it seems sensible to implement those strategies already shown to be effective in the general population."

Abstract - Lee
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Abstract - Di Angelantonio
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Editorial (subscription or payment may be required)


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