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Prior Aspirin Use Is Marker for Recurrent MI Risk After ACS

Last Updated: October 13, 2010.

Patients with a history of aspirin use who experience an incident of acute coronary syndrome (ACS) are at modestly higher risk of recurrent myocardial infarction (MI), but not mortality, compared with non-prior aspirin users, according to a study in the Oct. 19 issue of the Journal of the American College of Cardiology.

WEDNESDAY, Oct. 13 (HealthDay News) -- Patients with a history of aspirin use who experience an incident of acute coronary syndrome (ACS) are at modestly higher risk of recurrent myocardial infarction (MI), but not mortality, compared with non-prior aspirin users, according to a study in the Oct. 19 issue of the Journal of the American College of Cardiology.

Jonathan D. Rich, M.D., of the University of Chicago, and colleagues analyzed data on 66,443 ACS patients from the Thrombolysis in Myocardial Infarction (TIMI) trials. The researchers compared prior aspirin users with non-prior users by ACS type, total mortality, and a composite end point of death, MI, recurrent ischemia, or stroke.

Prior aspirin users tended to be older (63 versus 59) and had more risk factors and evidence of heart disease, such as MI, angina, and prior interventions, than those without prior aspirin use. The researchers found no difference in mortality between the two groups at 30 days or at the last follow-up. A modest association was found for prior aspirin use and recurrent MI (odds ratio, 1.26) and for the composite end point (OR, 1.16).

"Prior aspirin use was associated with more comorbidities and coronary disease and a higher risk of recurrent MI, but not mortality. As such, it should best be considered a marker of a patient population at high risk for recurrent adverse events after ACS," the authors write.

Multiple study authors reported financial ties to pharmaceutical and/or medical device companies.

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