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HIV Tropism Testing Guidelines Established

Last Updated: March 22, 2011.

The European Consensus Group on the clinical management of tropism testing has established guidelines for tropism testing prior to the initiation of maraviroc therapy for HIV; the guidelines have been published online March 22 in The Lancet Infectious Diseases.

TUESDAY, March 22 (HealthDay News) -- The European Consensus Group on the clinical management of tropism testing has established guidelines for tropism testing prior to the initiation of maraviroc therapy for HIV; the guidelines have been published online March 22 in The Lancet Infectious Diseases.

Linos P.R. Vandekerckhove, M.D., of Ghent University Hospital in Belgium, and colleagues compiled guidelines for the clinical management of tropism testing -- testing the ability of viruses to enter and infect specific host cells based on receptor binding -- using input from 60 panelists from 31 European countries.

The researchers recommend HIV-tropism testing in drug-naive patients who may be susceptible to toxic effects or who have limited drug choices, those who have low tolerance for or experience toxic effects from current medication or who have central nervous system pathology, and those for whom treatment has failed. They also assessed available genotypic and phenotypic tests for tropism, none of which have been clinically validated.

"Current data lend support to both the use of population genotyping and the commercially available enhanced sensitivity Trofile assay for establishing co-receptor tropism. For practical reasons, genotypic population sequencing is the preferred method in Europe," the authors write.

Several panel members disclosed financial ties to pharmaceutical and/or medical device companies.

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