Create Account | Sign In: Author or Forum

Search Symptoms

Category: Cardiology | Family Medicine | Gynecology | Internal Medicine | Oncology | Pathology | Pharmacy | Journal

Back to Journal Articles

Hypertension Drugs Tied to Risk of Cancer Recurrence

Last Updated: April 25, 2011.

Angiotensin-converting enzyme inhibitors appear to be associated with an elevated risk of breast cancer recurrence in women, while beta blockers seem to have a protective effect, according to a study published online April 11 in Breast Cancer Research and Treatment.

MONDAY, April 25 (HealthDay News) -- Angiotensin-converting enzyme inhibitors (ACEi) appear to be associated with an elevated risk of breast cancer recurrence in women, while beta blockers (BBs) seem to have a protective effect, according to a study published online April 11 in Breast Cancer Research and Treatment.

Patricia A. Ganz, M.D., of the University of California in Los Angeles, and colleagues evaluated the association between BBs and/or ACEi and breast cancer recurrence, breast cancer-specific mortality, and overall mortality using observational data from the Life After Cancer Epidemiology Study cohort.

The investigators found 292 breast cancer recurrences, 174 breast cancer deaths, and 323 total deaths among 1,779 women, with 23 percent exposed to a BB and/or an ACEi. Cox proportional hazards models revealed that ACEi exposure was associated with cancer recurrence (hazard ratio [HR], 1.56), though not with cause-specific or overall mortality. In addition, combined ACEi and BB were associated with overall mortality (HR, 1.94). BB exposure was related to lower hazard of recurrence and cause-specific mortality. For recurrence and cause-specific mortality, BB combined with ACEi was related to a lower HR for the outcome than when ACEi alone was used.

"The findings from this study are provocative, and raise concerns about the potential harm of commonly prescribed ACEi therapy. Although the low event rates and small number of patients on BB limited our power to detect the potential benefits of individual BB medications, the main findings for BB are consistent with the hypothesis that this class of drugs may be risk reducing," the authors write.

Abstract
Full Text (subscription or payment may be required)


Previous: Asthma May Increase Risk of Erectile Dysfunction Next: Getting Right Amount of Sleep May Help With Weight Loss

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion: