April 2011 Briefing - GastroenterologyLast Updated: May 02, 2011.
Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for April 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Increasing Cancer Burden Projected for Ethnic Minorities
THURSDAY, April 28 (HealthDay News) -- Consideration of genetic, ethnic, biologic, and sociological factors is necessary to appropriately diagnose and treat cancer in all U.S. subpopulations, according to the President's Cancer Panel 2009 to 2010 report published April 28.
New Approaches Useful for Management of IBD
WEDNESDAY, April 27 (HealthDay News) -- New therapeutic approaches may be useful in management of inflammatory bowel disease (IBD), specifically for inducing remission and preventing relapse in ulcerative colitis (UC), and Crohn's disease (CD), according to a review published as a supplement to the April issue of The American Journal of Gastroenterology.
Activated CTNNB1 Linked to Survival in Obese CRC Patients
WEDNESDAY, April 27 (HealthDay News) -- Cadherin-associated protein β 1 (CTNNB1) activation is associated with improved colorectal cancer-specific and overall survival in patients with colorectal cancer with a body mass index (BMI) of 30 kg/m² or more, according to a study published online April 27 in the Journal of the American Medical Association.
Vitamin E and Metformin Don't Improve Pediatric NAFLD
WEDNESDAY, April 27 (HealthDay News) -- For pediatric patients with nonalcoholic fatty liver disease (NAFLD), neither treatment with vitamin E nor metformin significantly reduces alanine aminotransferase (ALT) levels compared to placebo, according to a study published in the April 27 issue of the Journal of the American Medical Association.
Black Cancer Patients More Willing to Pay to Extend Life
TUESDAY, April 26 (HealthDay News) -- Black cancer patients are more willing to expend their personal financial resources in order to extend life compared to white cancer patients, according to a study published online April 26 in Cancer.
Restricted Diet Lowers Triglycerides in Fatty Liver
TUESDAY, April 26 (HealthDay News) -- Restricted intake of carbohydrates or calories for two weeks significantly reduces hepatic triglycerides in individuals with nonalcoholic fatty liver disease (NAFLD), according to a study published in the May issue of The American Journal of Clinical Nutrition.
Smoking Cessation May Prevent Cancer in Liver Recipients
MONDAY, April 25 (HealthDay News) -- Liver transplant recipients who quit smoking after transplantation have a lower incidence of smoking-related malignancies (SRMs) compared with patients who continue smoking, according to a study published in the April issue of Liver Transplantation.
Three Enterotypes Identified in Human Gut
THURSDAY, April 21 (HealthDay News) -- Three different clusters of microbiota, known as enterotypes, which are not nation or continent specific, have been identified in the gut and may be associated with different human characteristics, according to a study published online April 20 in Nature.
Off-Label Use of Recombinant Factor VIIa High
WEDNESDAY, April 20 (HealthDay News) -- Off-label use of recombinant factor VIIa (rFVIIa) in the hospital setting greatly exceeds use for approved indications; off-label use does not appear to reduce mortality and may increase the risk for thromboembolism, according to research published in the April 19 issue of the Annals of Internal Medicine.
Colorectal Cancer Mortality Varies Between Hospitals
FRIDAY, April 15 (HealthDay News) -- Thirty-day postoperative mortality following major colorectal cancer surgery varies significantly between hospitals, according to a study published online April 12 in Gut.
Smoking After Cancer Diagnosis Worsens Quality of Life
MONDAY, April 11 (HealthDay News) -- Caregiver mental quality of life (QoL) is worse in lung and colorectal patient-caregiver dyads in which one member of the dyad smokes, according to a study published in the February issue of Cancer Epidemiology, Biomarkers & Prevention.
H. pylori Therapy Effective in Half of Treated Children
MONDAY, April 11 (HealthDay News) -- A novel eradication therapy for Helicobacter pylori (H. pylori) was effective in only half of asymptomatic children tested; regardless, there were no changes in iron stores among all members of the four-arm group, though children whose infection was eradicated had higher serum ferritin levels, according to two articles published in the March issue of the Journal of Pediatric Gastroenterology & Nutrition.
Imatinib Reduces Cutaneous Systemic Sclerosis Symptoms
MONDAY, April 11 (HealthDay News) -- Imatinib mesylate is well tolerated by patients with diffuse cutaneous systemic sclerosis (dcSSc) with improvement in skin thickening and forced vital capacity (FVC), according to a study published online March 11 in the Annals of the Rheumatic Diseases.
National Use of Diagnostic CT Colonography Has Tripled
MONDAY, April 11 (HealthDay News) -- Since the start of the Current Procedural Terminology tracking codes, nationwide use of diagnostic computed tomographic colonography (CTC) by Medicare beneficiaries has tripled, according to a study published in the April issue of the Journal of the American College of Radiology.
FDA OKs Rapid Test to Spot C. difficile Infection
FRIDAY, April 8 (HealthDay News) -- A test designed to rapidly detect the genetic fingerprint of Clostridium difficile bacterial infection has been approved by the U.S. Food and Drug Administration.
Telaprevir Increases Second-Phase Hepatitis C Decline
FRIDAY, April 8 (HealthDay News) -- Analysis of the kinetics of telaprevir treatment for hepatitis C virus (HCV) shows a rapid second-phase viral decline, which may allow for shorter duration of treatment, according to a study published online March 7 in Hepatology.
Nonalcoholic Fatty Liver Disease Tied to Higher CRC Risk
FRIDAY, April 8 (HealthDay News) -- Patients with nonalcoholic fatty liver disease (NAFLD) undergoing screening colonoscopy have more early or precursor colorectal carcinoma (CRC) lesions compared to subjects without NAFLD, according to a study published online March 17 in the Journal of Internal Medicine.
'Global Trigger Tool' Identifies 10 Times More Errors
THURSDAY, April 7 (HealthDay News) -- Use of the new Global Trigger Tool, developed by the Institute for Healthcare Improvement, detects at least 10 times more adverse events than other methods currently in use, according to a study published in the April issue of Health Affairs.
Asian Ethnicity May Predict Hep B-Dominant Dual Infection
THURSDAY, April 7 (HealthDay News) -- Asians who are infected with both hepatitis B virus (HBV) and hepatitis C virus (HCV) are more likely to have HBV-dominant disease, compared to dually infected non-Asians, according to a study published online March 21 in Hepatology.
Longer Breast-Feeding Tied to More Protective Adipokines
THURSDAY, April 7 (HealthDay News) -- The duration of breast-feeding is associated with higher maternal ghrelin and pancreatic peptide YY (PYY) levels at three years postpartum, independent of other risk factors for metabolic disease, according to a study published in the April issue of Diabetes.
New Yellow Fever Vaccine Safe and Effective
THURSDAY, April 7 (HealthDay News) -- A new vaccine against yellow fever that contains inactivated yellow fever antigen shows promise as a safe alternative to live vaccine, according to research published in the April 7 issue of the New England Journal of Medicine.
Cancer Rates, Cancer Mortality Rates Falling in U.S.
FRIDAY, April 1 (HealthDay News) -- Newly diagnosed cancer rates and cancer-related mortality rates in the United States are steadily declining, according to the "Annual Report to the Nation on the Status of Cancer," published online March 31 in the Journal of the National Cancer Institute.
Inflammatory Bowel Disease Impacts Exercise Capacity
FRIDAY, April 1 (HealthDay News) -- Pediatric patients with inflammatory bowel disease (IBD) exhibit impaired exercise capacity compared to reference values, according to a study published online Dec. 13 in The Journal of Pediatrics.
Autoimmune Diseases Number Two Cause of Chronic Illness
FRIDAY, April 1 (HealthDay News) -- Autoimmune diseases are the second leading cause of chronic illness in the United States and constitute a major direct and indirect economic burden to the U.S. health care system, according to a report released by the American Autoimmune Related Diseases Association (AARDA) on March 22 at a congressional briefing.
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