July 2011 Briefing - OrthopedicsLast Updated: August 01, 2011.
Here are what the editors at HealthDay consider to be the most important developments in Orthopedics for July 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Cementless Implants Tied to Improved Hip Implant Survival
FRIDAY, July 29 (HealthDay News) -- Total hip arthroplasty performed with cementless implants is associated with improved implant survival rates compared to its cemented counterpart, according to a study published in the July 20 issue of The Journal of Bone & Joint Surgery.
VTE Rates Post Knee Arthroplasty Increased '97-'07
THURSDAY, July 28 (HealthDay News) -- The rate of venous thromboembolism following knee arthroplasty has increased from 1997 to 2007, with a higher risk among patients with a history of cardiovascular disease or a prior venous thromboembolism, according to a study published in the July 20 issue of The Journal of Bone & Joint Surgery.
Somatic Mosaicism in AKT1 Causes Proteus Syndrome
WEDNESDAY, July 27 (HealthDay News) -- A somatic activating mutation in the oncogene AKT1 has been found to cause Proteus syndrome, a condition characterized by the overgrowth of skin, connective tissue, brain, and other tissues, according to a study published online July 27 in the New England Journal of Medicine.
Smoking Tied to Increase in Post-Arthroplasty Complications
WEDNESDAY, July 27 (HealthDay News) -- Pre-operative smoking status is a significant predictor of 30-day postoperative complications and mortality at one year in patients undergoing elective primary total knee replacement or primary total hip replacement surgery (TKR/THR), according to a study published online July 18 in Arthritis Care & Research.
AVI-4658 Safe and Effective for Duchenne Muscular Dystrophy
TUESDAY, July 26 (HealthDay News) -- The phosphorodiamidate morpholino oligomer AVI-4658 has been found to safely induce new dystrophin protein expression in a significant dose-dependent manner in patients with Duchenne muscular dystrophy (DMD), according to a study published online July 25 in The Lancet.
Axial Neck Loading Linked to Sports-Related Spine Injury
FRIDAY, July 22 (HealthDay News) -- Sports-related cervical spine injuries can be produced by an axial loading of the neck, with the impact causing high peak linear and rotational acceleration of the head, according to a letter published in the July 21 issue of the New England Journal of Medicine.
FDA: Possible Bisphosphonate-Esophageal CA Link Reviewed
FRIDAY, July 22 (HealthDay News) -- The U.S. Food and Drug Administration has notified health care professionals and patients that the use of oral bisphosphonates does not appear to increase the risk of esophageal cancer, with the agency currently not recommending endoscopic screening of asymptomatic patients.
Acute Nondisplaced Scaphoid Fractures Heal Without Surgery
TUESDAY, July 19 (HealthDay News) -- Most acute, nondisplaced, scaphoid fractures in children and adolescents heal with nonoperative treatment, but those presenting late or with displacement have a lower union rate, according to a study published in the July 6 issue of The Journal of Bone & Joint Surgery.
Review: Exercise = Less Bone Loss in Postmenopausal Women
TUESDAY, July 19 (HealthDay News) -- Exercise is suggested to have a small but statistically significant effect on preventing bone mineral density (BMD) loss in postmenopausal women, according to a meta-analysis published in the July issue of the Cochrane Database of Systematic Reviews.
Most Pediatric C3 Pedicles Too Thin for Safe Screw Insertion
MONDAY, July 18 (HealthDay News) -- Although the majority of pediatric C3 pedicles are too thin for safe cervical pedicle screw (CPS) insertion, at all other levels pedicle morphometrics allow for safe application of 3 mm CPS, according to a study published in the July 15 issue of Spine.
Study Design Bias Suspected in Industry Trials on rhBMP-2
FRIDAY, July 15 (HealthDay News) -- U.S. Food and Drug Administration documents and subsequent publications show that recombinant human bone morphogenetic protein-2 (rhBMP-2) is associated with a 10 to 50 percent higher rate of adverse events (AE) than reported in original industry-based trials, according to a review published in the June issue of The Spine Journal.
High Rate of Osteolysis in Fusions Using Morphogenetic Protein
FRIDAY, July 15 (HealthDay News) -- Use of bone morphogenetic protein (BMP) in transforaminal lumbar interbody fusion (TLIF) is associated with a high rate of adjacent vertebral body osteolysis in the first three to six months post-surgery, with osteolysis persisting at one-year fusion in most cases, according to a study published in the June issue of The Spine Journal.
Post-Surgery VTE Prophylaxis Use Varies Among Hospitals
FRIDAY, July 15 (HealthDay News) -- The use of venous thromboembolism (VTE) prophylaxis after spinal fusion surgery varies widely in U.S. hospitals, according to a study published in the July issue of the Journal of Thrombosis and Haemostasis.
BMI Changes Predictive of Bilateral Knee Pain in Women
FRIDAY, July 15 (HealthDay News) -- Changes in body mass index (BMI) are associated with year 15 (Y15) bilateral knee pain in women irrespective of radiographic knee osteoarthritis (RKOA) status, according to a study published online July 7 in Arthritis Care & Research.
Large Bone Volume Harvested in Posterolateral Lumbar Fusion
WEDNESDAY, July 13 (HealthDay News) -- Large volumes of local bone can be harvested during posterolateral lumbar fusion surgery, according to a study published in the June issue of The Spine Journal.
New Model Correctly Classifies Low Back Pain Patients
WEDNESDAY, July 13 (HealthDay News) -- A new logistic regression model using kinematic analysis variables from two everyday tasks can correctly classify 97.3 percent of patients with nonspecific low back pain (LBP), according to a study published in the July 15 issue of Spine.
Aledronate Tied to Less BMD Loss Around Femoral Implants
TUESDAY, July 12 (HealthDay News) -- Bone mineral density (BMD) is maintained in all regions around femoral implants in patients undergoing hip arthroplasty who are treated with alendronate, whereas in the lumbar spine, BMD is higher in patients treated with alendronate or alfacalcidol, according to a study published in the July 6 issue of The Journal of Bone & Joint Surgery.
Overweight, Exercise Tied to Increased Joint Replacement Risk
TUESDAY, July 12 (HealthDay News) -- Men who are overweight and engage in vigorous exercise have an increased risk of undergoing total joint replacement (TJR), according to a study published online July 11 in Arthritis & Rheumatism.
No Benefits of Botulinum Toxin Found for Chronic Neck Pain
MONDAY, July 11 (HealthDay News) -- There is no evidence confirming either clinically important or statistically significant benefits of botulinum toxin type-A (BoNT-A) for chronic neck pain, with or without cervicogenic headache, according to a review published in the July issue of the Cochrane Database of Systematic Reviews.
Conservative Scoliosis Treatment Tied to Lower Self-Concept
WEDNESDAY, July 6 (HealthDay News) -- Conservative treatment of adolescent scoliosis may decrease self-concept scores, according to a study published in the July 1 issue of Spine.
No Clinical Difference With Spinal Manipulative Therapy
THURSDAY, June 30 (HealthDay News) -- Despite having a small but significant effect, spinal manipulative therapy (SMT) does not appear to offer clinically relevant short-term pain relief and improved function for patients with chronic low-back pain compared to other interventions, according to a review published in the June 1 issue of Spine.
Massage Therapy Relieves Symptoms of Low Back Pain
TUESDAY, July 5 (HealthDay News) -- Patients with chronic low back pain have shown improved function and decreased pain with massage therapy, according to a study published in the July 5 issue of the Annals of Internal Medicine.
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