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Interstitial Cystitis Subtypes Have Distinct Differences

Last Updated: August 11, 2011.

In women with interstitial cystitis/painful bladder syndrome (IC/PBS), the number of comorbid diagnoses/symptoms differ substantially between the ulcerative and nonulcerative IC/PBS subtypes and controls, according to a study published in the August issue of Urology.

THURSDAY, Aug. 11 (HealthDay News) -- In women with interstitial cystitis/painful bladder syndrome (IC/PBS), the number of comorbid diagnoses/symptoms differ substantially between the ulcerative (ULC) and nonulcerative (N-ULC) IC/PBS subtypes and controls, according to a study published in the August issue of Urology.

Kenneth M. Peters, M.D., from the William Beaumont Hospital in Royal Oak, Mich., and colleagues compared comorbid diagnoses/symptoms in 178 women with N-ULC IC/PBS, 36 women with ULC IC/PBS, and 425 controls without IC/PBS. Participants had similar demographic characteristics, except that patients with ULC IC/PBS were older (average age, 63 years) and fewer were employed. IC/PBS subtype was determined by hydrodistention reports. Data were collected through a mailed survey assessing 21 diagnoses, which included standardized questionnaires assessing IC/PBS symptoms (interstitial cystitis symptom/problem indexes [ICSI-PI]), and undiagnosed fibromyalgia, irritable bowel syndrome, and depression (symptom intensity score [SIS], Rome III functional bowel questionnaire, and the Center for Epidemiologic Studies Depression Scale [CES-D]).

The investigators found that there were significantly more chronic diagnoses in the N-ULC group than in the ULC and control groups (average diagnosis, 3.5, 2.3, and 1.2, respectively). Compared to patients with ULC IC/PBS, significantly more patients with N-ULC IC/PBS had fibromyalgia, migraines, temporomandibular joint disorder, and higher CES-D and SIS scores. The ULC IC/PBS group had significantly smaller mean bladder capacity than N-ULC, and voided more frequently during the day and nighttime. Scores for ICSI-PI and Rome III were not significantly different between the N-ULC and ULC IC/PBS groups.

"Notable differences in the number of comorbid diagnoses and symptoms were seen between IC/PBS subtypes and controls," the authors write.

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