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Women With Endometriosis Have a Higher Risk of IBD

Last Updated: December 22, 2011.

Women with endometriosis have a significantly increased risk of developing inflammatory bowel disease, including Crohn's disease and ulcerative colitis, compared to those without the reproductive disorder, according to a large Danish study published online Dec. 19 in Gut.

THURSDAY, Dec. 22 (HealthDay News) -- Women with endometriosis have a significantly increased risk of developing inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, compared to those without the reproductive disorder, according to a large Danish study published online Dec. 19 in Gut.

Tine Jess, M.D., Dr.Med.Sci., of the Statens Serum Institut in Copenhagen, Denmark, and colleagues identified 37,661 Danish women hospitalized with endometriosis between 1977 and 2007 and followed their health from the first recorded date of hospital contact for endometriosis until the date of IBD diagnosis, emigration, disappearance, death, or end of study (Dec. 31, 2007).

The researchers found that, during an average of 13 years of follow-up, 320 women developed IBD (228 with ulcerative colitis and 92 with Crohn's). Women with endometriosis had a 50 percent increased risk of developing IBD compared with women in the general Danish population, and the risk persisted after 20 years. When the analysis was restricted to women whose endometriosis was verified surgically, the risk increased to 80 percent.

"This study of a nationwide cohort of 37,661 women with endometriosis showed a significantly increased risk of IBD in women with endometriosis, which was most pronounced in women with surgically verified endometriosis and persisted after 20 years of follow-up," the authors write.

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