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December 2011 Briefing - Cardiology

Last Updated: January 02, 2012.

Here are what the editors at HealthDay consider to be the most important developments in Cardiology for December 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

High-Sensitivity CRP Predicts Mortality in A-Fib Patients

THURSDAY, Dec. 29 (HealthDay News) -- Higher levels of high-sensitivity C-reactive protein (hs-CRP) are associated with increased all-cause and cardiovascular mortality in patients with atrial fibrillation (AF), independent of other risk factors, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

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Enoxaparin Doesn't Reduce Death Rate for Acutely Ill

WEDNESDAY, Dec. 28 (HealthDay News) -- For hospitalized, acutely ill medical patients, use of enoxaparin plus elastic stockings with graduated compressions, does not reduce the rate of death from any cause at 30 days, according to a study published in the Dec. 29 issue of the New England Journal of Medicine.

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New Equation Accurately Predicts Body Fat Percentage

WEDNESDAY, Dec. 28 (HealthDay News) -- A new prediction equation estimates body fat percentage (BF%) in adults with a low error rate and acceptable accuracy and may be a good first-screening tool for identifying patients at cardiovascular and type 2 diabetes risk, according to research published online Dec. 16 in Diabetes Care.

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Irradiation of Left Breast Linked to Coronary Stenosis Risk

WEDNESDAY, Dec. 28 (HealthDay News) -- Women with irradiated left sided breast cancer (BC) have an increased risk of high-grade coronary artery stenosis in the mid and distal left anterior descending artery and distal diagonal (mdLAD + dD), according to a study published online Dec. 27 in the Journal of Clinical Oncology.

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No Correlation ID'd Between CYP2C19 Genotype, CVD Events

TUESDAY, Dec. 27 (HealthDay News) -- Although CYP2C19 genotype correlates with clopidogrel response and platelet aggregation, there is no evidence of a clinically significant association between CYP2C19 genotype and cardiovascular disease (CVD) events, according to a meta-analysis published in the Dec. 28 issue of the Journal of the American Medical Association.

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Serial Change in hsTnI or cTnI Accurately Rule In/Out AMI

TUESDAY, Dec. 27 (HealthDay News) -- For patients admitted with suspected acute coronary syndrome (ACS), use of highly sensitive troponin I (hsTnI) or contemporary troponin I (cTnI) assays on admission, and changes in their levels within three hours, can confirm the diagnosis of acute myocardial infarction (AMI), according to a study published in the Dec. 28 issue of the Journal of the American Medical Association.

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Perceptions of Inappropriate Care Prevalent Among ICU Staff

TUESDAY, Dec. 27 (HealthDay News) -- Perceptions of inappropriate care are prevalent among intensive care unit (ICU) clinicians in Europe and Israel, according to a study published in the Dec. 28 issue of the Journal of the American Medical Association.

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Extreme Preemies Can Achieve Normal Exercise Capacity

TUESDAY, Dec. 27 (HealthDay News) -- Individuals born extremely preterm can achieve normal exercise capacity as well as aerobic capacity and response to physical training comparable to their peers born at term, according to a study published online Dec. 26 in Pediatrics.

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Improved CVD Risk Prediction Model in Diabetes Identified

TUESDAY, Dec. 27 (HealthDay News) -- For patients with type 2 diabetes and no history of cardiovascular diseases (CVDs), the ability of the Framingham risk score (FRS) to predict development of CVD is improved by combining it with carotid intima-media thickness (IMT) measurement, according to a study published in the January issue of Diabetes Care.

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Smoking During Pregnancy Affects Children's Vasculature

TUESDAY, Dec. 27 (HealthDay News) -- Parental smoking during pregnancy affects children's arterial structure and function in early life; and interventions that encourage parents to quit smoking for their children's benefit may increase parental quit rates, according to two studies published online Dec. 26 in Pediatrics.

Abstract - Geerts
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Abstract - Rosen
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Coronary MRI Good Alternative to SPECT for CHD Diagnosis

MONDAY, Dec. 26 (HealthDay News) -- For patients with suspected coronary heart disease, a multiparametric cardiovascular magnetic resonance (CMR) protocol has better sensitivity and negative predictive value, and similar specificity as single-photon emission computed tomography (SPECT), according to a study published online Dec. 23 in The Lancet.

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Simvastatin Beats Ezetimibe in Anti-inflammatory Effects

THURSDAY, Dec. 22 (HealthDay News) -- For patients with hypercholesterolemia, simvastatin is superior to ezetimibe for producing lymphocyte-suppression and systemic anti-inflammatory and endothelial protective effects, according to a study published in the January issue of the Journal of Internal Medicine.

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Chlorthalidone Treatment Offers Long-Term Survival Benefits

TUESDAY, Dec. 20 (HealthDay News) -- Chlorthalidone treatment for isolated systolic hypertension, among participants of the Systolic Hypertension in the Elderly Program (SHEP) trial, is associated with improved cardiovascular mortality, according to a study published in the Dec. 21 issue of the Journal of the American Medical Association.

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Long-Term Increase in Resting Heart Rate Ups Mortality

TUESDAY, Dec. 20 (HealthDay News) -- An increase in resting heart rate (RHR) over a 10-year period is associated with an increased risk of dying from ischemic heart disease (IHD), according to a study published in the Dec. 21 issue of the Journal of the American Medical Association.

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Antiarrythmic Drug Associated With Adverse Cardiac Events

TUESDAY, Dec. 20 (HealthDay News) -- The heart drug Multaq (dronedarone) should not be prescribed to patients with permanent atrial fibrillation because of an increased risk of serious cardiovascular events, including death, according to a Dec. 19 Drug Safety Communication from the U.S. Food and Drug Administration.

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Vitamin D, Calcium Found to Cut Fracture, Cancer Risk

TUESDAY, Dec. 20 (HealthDay News) -- Vitamin D supplementation can reduce the risk of fracture and cancer; and although there is a biological association between vitamin D deficiency and cardiovascular disease (CVD), there is no evidence that vitamin D supplementation prevents CVD, according to two reviews published in the Dec. 20 issue of the Annals of Internal Medicine.

Abstract - Chung
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Abstract - Greevy and Williams
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Blood Pressure in Middle Age Affects Lifetime CVD Risk

TUESDAY, Dec. 20 (HealthDay News) -- Changes in blood pressure (BP) during middle age significantly impact lifetime risk (LTR) for cardiovascular disease (CVD), with a possible dose-response effect for the number of years with high BP on the LTR of CVD, coronary heart disease, and stroke, according to research published online Dec. 19 in Circulation.

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Physician Opinions on Benefits of Open Visit Notes Vary

MONDAY, Dec. 19 (HealthDay News) -- Primary care physicians (PCPs) have varied opinions about open access to doctors' notes; and most users of a personal health record (PHR) system are interested in sharing access to their information, according to two studies published in the Dec. 20 issue of the Annals of Internal Medicine.

Abstract - Walker
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Abstract - Zulman
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Nearly One-Half of Short-Term PCI Deaths Occur Post-Discharge

MONDAY, Dec. 19 (HealthDay News) -- Nearly 40 percent of all post-percutaneous coronary intervention (PCI) short-term deaths occur after discharge and within 30 days of the procedure, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

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Omega-3 Index Not Linked to Bleeding in Acute MI

MONDAY, Dec. 19 (HealthDay News) -- For patients with acute myocardial infarction (AMI), there is no association between the omega-3 fatty acid index (red blood cell eicosapentaenoic acid plus docosahexaenoic acid) and bleeding, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

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Suboptimal Intensive Statin Therapy Use After ACS

MONDAY, Dec. 19 (HealthDay News) -- Intensive statin therapy (IST) use during hospitalization is suboptimal following acute coronary syndrome (ACS), and there is poor persistence after discharge, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

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New Device Approved for Children With Heart Failure

FRIDAY, Dec. 16 (HealthDay News) -- A cardiac assist device that's designed to keep a child with heart failure alive until doctors can find a donor heart has been approved by the U.S. Food and Drug Administration.

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Quitting Smoking Improves Happiness, Quality of Life

FRIDAY, Dec. 16 (HealthDay News) -- People who successfully quit smoking are happier and more satisfied with their lives than people who continue to smoke, according to a study published online Dec. 10 in the Annals of Behavioral Medicine.

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AHA: U.S. Cardiovascular Disease Burden Still High

THURSDAY, Dec. 15 (HealthDay News) -- Despite a decrease in the rate of death attributable to cardiovascular disease and stroke, the burden of disease is still high, according to the American Heart Association's (AHA's) Heart Disease and Stroke Statistical Update 2012, published online Dec. 15 in Circulation.

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Physical Activity Tied to Sexual Function in Young Men

THURSDAY, Dec. 15 (HealthDay News) -- For young, healthy men, leading a sedentary lifestyle is associated with increased sexual dysfunction on various domains of the International Index of Erectile Function (IIEF), according to a study published online Dec. 6 in The Journal of Sexual Medicine.

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High Prevalence of Obesity Found Among Adults in Spain

THURSDAY, Dec. 15 (HealthDay News) -- The prevalence of obesity is high in the adult population of Spain and is affected by sociodemographic factors, including age and education levels, according to a study published online Dec. 12 in Obesity Reviews.

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Statins Lower Death Risk in Adults Hospitalized With Flu

THURSDAY, Dec. 15 (HealthDay News) -- In adults hospitalized for influenza virus infections, administration of statins before or during the hospitalization is associated with a reduced risk of mortality, according to a study published online Dec. 13 in the Journal of Infectious Diseases.

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Concurrent-, Staged-Bilateral Knee Arthroplasty Compared

THURSDAY, Dec. 15 (HealthDay News) -- Simultaneous-bilateral arthroplasty is associated with reduced incidence of periprosthetic joint infection and malfunction, and with increased cardiovascular risk, compared with staged-bilateral arthroplasty, according to a study published in the Dec. 7 issue of The Journal of Bone & Joint Surgery.

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CPAP Improves BP, Metabolic Abnormalities in Sleep Apnea

WEDNESDAY, Dec. 14 (HealthDay News) -- For patients with severe obstructive sleep apnea, three months of continuous positive airway pressure (CPAP) therapy is associated with reduced blood pressure, and partial reversal of metabolic abnormalities, according to a study published in the Dec. 15 issue of the New England Journal of Medicine.

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Regional Rehospitalization Rate Tied to Overall Admissions

WEDNESDAY, Dec. 14 (HealthDay News) -- For patients with congestive heart failure or pneumonia, regional rates of rehospitalizations are substantially associated with overall admission rates at 30, 60, and 90 days, according to a study published in the Dec. 15 issue of the New England Journal of Medicine.

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PCI Outcomes No Worse in Centers Without On-Site Surgery

TUESDAY, Dec. 13 (HealthDay News) -- Similar rates of in-hospital mortality and emergency coronary artery bypass grafting (CABG) surgery for percutaneous coronary intervention (PCI) are seen at centers with and without on-site surgery, according to a review published in the Dec. 14 issue of the Journal of the American Medical Association.

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Over and Under Nutrition Tied to Increased Stroke Risk

TUESDAY, Dec. 13 (HealthDay News) -- Evidence suggests that under and over nutrition increase the risk of stroke, and questions the role of antioxidant, vitamin, and calcium supplements, according to a review published in the January issue of The Lancet Neurology.

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Infection Prevention Up in VA, Non-Federal Hospitals

TUESDAY, Dec. 13 (HealthDay News) -- From 2005 to 2009, there was a significant increase in the use of hospital-acquired infection (HAI) prevention practices in non-federal and Veterans Affairs (VA) hospitals, according to a study published online Dec. 6 in the Journal of General Internal Medicine.

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ADHD Med Use Not Tied to Increased Cardiovascular Risk

MONDAY, Dec. 12 (HealthDay News) -- Current or new use of attention-deficit/hyperactivity disorder (ADHD) medications is not associated with an increased risk for serious cardiovascular events (myocardial infarction [MI], sudden cardiac death [SCD], or stroke), according to a study published online Dec. 12 in the Journal of the American Medical Association.

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Khat Ups Adverse Outcomes in Acute Coronary Syndrome

MONDAY, Dec. 12 (HealthDay News) -- For patients with acute coronary syndrome, chewing khat is associated with an increased risk of recurrent ischemia, heart failure, stroke, and death, according to a study published in the Dec. 13 issue of Circulation.

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Preterm Birth Impairs Baroreflex Sensitivity in Infants

MONDAY, Dec. 12 (HealthDay News) -- Preterm birth alters the normal maturational increase in baroreflex sensitivity (BRS), which results in significantly reduced BRS during quiet sleep (QS), at a corrected age (CA) of 5 to 6 months, according to a study published online Dec. 12 in Pediatrics.

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Meds Reduce Stroke Risk in Patients With Prehypertension

FRIDAY, Dec. 9 (HealthDay News) -- The administration of blood pressure-lowering medication to people in a prehypertensive range appears to significantly reduce their risk of stroke, according to research published online Dec. 8 in Stroke.

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Factors Affecting Micro-RNA Detection Accuracy Identified

FRIDAY, Dec. 9 (HealthDay News) -- Accurate detection and quantitation of circulating microRNAs (miRNAs) is affected by inherent differences in plasma samples, methods used for their collection and analysis, and the presence of specific inhibitors in plasma, according to a study published online Dec. 9 in the Journal of Molecular Diagnostics.

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Endurance Exercises Tied to Right Ventricular Dysfunction

THURSDAY, Dec. 8 (HealthDay News) -- Myocardial dysfunction following endurance exercises predominantly affects the right ventricle (RV), according to a study published online Dec. 6 in the European Heart Journal.

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Androgen Deprivation in Prostate Cancer Not Tied to CVD Death

TUESDAY, Dec. 6 (HealthDay News) -- Use of androgen deprivation therapy (ADT) is not associated with cardiovascular death, but is correlated with significantly lower prostate cancer-specific mortality (PCSM) and all-cause mortality, according to a review and meta-analysis published in the Dec. 7 issue of the Journal of the American Medical Association.

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LV Dyssynchrony Has Prognostic Value After Acute MI

TUESDAY, Dec. 6 (HealthDay News) -- In patients admitted with ST-segment elevation acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI), left ventricular (LV) dyssynchrony is a strong predictor of long-term mortality and hospitalization for heart failure, over known clinical and echocardiographic risk factors, according to research published in the Dec. 15 issue of The American Journal of Cardiology.

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Medical Students Fail to ID Hand Hygiene Indications

MONDAY, Dec. 5 (HealthDay News) -- Medical students who are about to start the clinical phase of their education have a lack of knowledge regarding the correct indications for hand disinfection, according to a study published in the December issue of the American Journal of Infection Control.

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Eating Little or No Fish Ups Young Women's CVD Risk

MONDAY, Dec. 5 (HealthDay News) -- Young and initially healthy women who consume little or no fish and long-chain n-3 polyunsaturated fatty acids (LCn3FAs) have an increased risk of cardiovascular disease, according to a study published online Dec. 5 in Hypertension.

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Cardiorespiratory Fitness, Not BMI, Linked to Mortality

MONDAY, Dec. 5 (HealthDay News) -- Men who maintain or improve their cardiorespiratory fitness (fitness) have a reduced risk of all-cause and cardiovascular disease (CVD) mortality, irrespective of body mass index (BMI) change, according to a study published in the Dec. 6 issue of Circulation.

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C. difficile Infection Ups Duration of Hospital Stay

MONDAY, Dec. 5 (HealthDay News) -- Hospital-acquired infection with Clostridium difficile (C. difficile) significantly and independently lengthens the duration of stay in the hospital, according to a study published online Dec. 5 in CMAJ, the journal of the Canadian Medical Association.

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High Incidence of Adverse Upper GI Events in MI Patients

MONDAY, Dec. 5 (HealthDay News) -- Patients with ST-segment elevation myocardial infarction, who undergo primary percutaneous coronary intervention and receive routine dual-antiplatelet therapy, have a high incidence of short- and long-term major adverse upper gastrointestinal events (MAUGIEs), according to a study published in the Dec. 15 issue of The American Journal of Cardiology.

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Youth Often Get Hypertension Rx From PCPs Who Treat Adults

MONDAY, Dec. 5 (HealthDay News) -- Nearly two-thirds of adolescents with primary hypertension who receive antihypertensive medication prescriptions get them from adult primary care physicians (PCPs), according to a study published online Dec. 5 in Pediatrics.

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Quality of Life Up in Obese A-Fib Patients Post-Ablation

FRIDAY, Dec. 2 (HealthDay News) -- For obese patients with atrial fibrillation (AF), but not for their non-obese counterparts, quality of life (QoL) scores improve significantly following catheter ablation, according to a study published in the December issue of Heart Rhythm.

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Salvianolic Acid B Suppress Maturation of Dendritic Cells

FRIDAY, Dec. 2 (HealthDay News) -- Salvianolic acid B (Sal B) -- a herb-derived, water-soluble antioxidant known to help prevent atherosclerosis -- effectively suppresses the maturation of human monocyte-derived dendritic cells (h-monDCs), according to a study published in the December issue of the British Journal of Pharmacology.

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First Generic Lipitor Approved

THURSDAY, Dec. 1 (HealthDay News) -- The first generic version of the cholesterol-lowering statin Lipitor (atorvastatin calcium) has been approved by the U.S. Food and Drug Administration.

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Diet High in Antioxidants Cuts Stroke Risk for Women

THURSDAY, Dec. 1 (HealthDay News) -- Following a diet with high total antioxidant capacity (TAC) is associated with reduced incidence of total stroke among women with no history of cardiovascular disease (CVD) and hemorrhagic stroke in those with a CVD history, according to a study published online Dec. 1 in Stroke.

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Anticoagulant Self-Monitoring Safe Option for Suitable Patients

THURSDAY, Dec. 1 (HealthDay News) -- Self-monitoring and self-management of oral coagulation is associated with a significant reduction in thromboembolic events and is a safe option for suitable patients of all ages, according to a review published online Dec. 1 in The Lancet.

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Waist-to-Height Ratio Beats BMI for Cardiometabolic Risk

THURSDAY, Dec. 1 (HealthDay News) -- Waist-to-height ratio (WHtR) is superior to waist circumference (WC) and body mass index (BMI) for detecting cardiometabolic risk in men and women of different nationalities and ethnicities, according to a review published online Nov. 23 in Obesity Reviews.

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