Create Account | Sign In: Author or Forum

Search Symptoms

Category: Pharmacy | Monthly Briefing

Back to Journal Articles

November 2014 Briefing - Pharmacy

Last Updated: December 01, 2014.

Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for November 2014. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

PCV13 Recommended for 6- to 18-Year-Olds at High Risk

WEDNESDAY, Nov. 26, 2014 (HealthDay News) -- Pneumococcal conjugate vaccine 13 (PCV13) should be administered to certain children aged 6 through 18 years who are at high risk of invasive pneumococcal disease (IPD), according to a policy statement published online Nov. 24 in Pediatrics.

Abstract
Full Text

FDA Advisory Panel Votes on Epidural Steroid Shots for Pain

WEDNESDAY, Nov. 26, 2014 (HealthDay News) -- An expert advisory panel to the U.S. Food and Drug Administration decided on Tuesday not to recommend the agency issue a strong warning against the general use of steroid injections for neck or back pain; however, there is concern regarding transforaminal cervical injections with particulate steroids.

Full Article
More Information

CDC: Most Americans With HIV Don't Have Virus Under Control

WEDNESDAY, Nov. 26, 2014 (HealthDay News) -- A U.S. Centers for Disease Control and Prevention report estimates that 70 percent of the 1.2 million Americans living with HIV in 2011 did not have their virus under control, even though combination drug therapies can effectively suppress the virus before it can develop into full-blown AIDS.

Full Article
More Information

Proton Pump Inhibitors Linked to Disruption of Gut Microbiome

WEDNESDAY, Nov. 26, 2014 (HealthDay News) -- Proton pump inhibitors may disrupt the microbiome of the digestive system, leading to infections and other complications, according to a small new study published online Nov. 25 in Microbiome.

Full Article
Full Text

Most Seniors Eligible for Statin Rx Under New Guidelines

TUESDAY, Nov. 25, 2014 (HealthDay News) -- Most older Americans qualify for treatment with statins under new guidelines for the treatment of blood cholesterol released late last year by the American College of Cardiology and the American Heart Association. The findings appear in a research letter published online Nov. 17 in JAMA Internal Medicine.

Full Article
Full Text (subscription or payment may be required)

Worse Outcomes With Deferral of ART Initiation in HIV-1

TUESDAY, Nov. 25, 2014 (HealthDay News) -- For individuals with HIV-1 infection, deferral of antiretroviral therapy (ART) beyond 12 months is associated with worse outcomes, according to research published online Nov. 24 in JAMA Internal Medicine.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Statins Not Tied to Women's Gonado-Sexual Dysfunction

TUESDAY, Nov. 25, 2014 (HealthDay News) -- Statin use is not associated with higher risk of gonado-sexual dysfunction in women, according to a study published online Nov. 10 in the Journal of Sexual Medicine.

Abstract
Full Text (subscription or payment may be required)

In Reperfusion Era, β-Blockers Have No Mortality Benefit in MI

MONDAY, Nov. 24, 2014 (HealthDay News) -- In the reperfusion era, β-blocker use has no mortality benefit in myocardial infarction, and patients discharged with high heart rate after myocardial infarction have increased mortality risk during the first year, according to research published in the October issue of The American Journal of Medicine.

Abstract - Bangalore
Full Text
Abstract - Seronde
Full Text

Digoxin for A-Fib Without Heart Failure Comes With Risks

MONDAY, Nov. 24, 2014 (HealthDay News) -- Digoxin is associated with increased risk of death and hospitalization among patients with atrial fibrillation but no evidence of heart failure, according to a study published online Nov. 20 in Circulation: Arrhythmia and Electrophysiology.

Full Article
Abstract
Full Text (subscription or payment may be required)

Eczema Cases Rising Among U.S. Children

MONDAY, Nov. 24, 2014 (HealthDay News) -- A growing number of children are being diagnosed with eczema -- but it can usually be eased with topical treatments, according to a new report by the American Academy of Pediatrics (AAP) published online Nov. 24 in Pediatrics.

Full Article
Abstract
Full Text

Successful Outcome Leads to Early Cessation of Sickle Cell Trial

MONDAY, Nov. 24, 2014 (HealthDay News) -- A clinical trial of hydroxyurea therapy for children with sickle cell anemia has been halted a year early because the results show it is a safe and effective way to manage the disease and reduce the risk of stroke. The announcement about the research, which was conducted at 25 medical centers in the United States and Canada, was made this week by the U.S. National Heart, Lung, and Blood Institute (NHLBI).

Full Article
More Information

Strategies Needed to Encourage Appropriate Antibiotic Selection

MONDAY, Nov. 24, 2014 (HealthDay News) -- Although primary care providers are generally familiar with guideline recommendations for antibiotic drug selection, they do not always comply with these guidelines, according to research published in the December issue of the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.

Full Text

Two Agents Show Promise for Hyperkalemia

MONDAY, Nov. 24, 2014 (HealthDay News) -- For patients with hyperkalemia, sodium zirconium cyclosilicate (ZS-9) and patiromer show promise for reducing potassium levels, according to two studies published online Nov. 21 in the New England Journal of Medicine.

Abstract - Packham
Full Text
Abstract - Weir
Full Text
Editorial

AMA: Gender Inequality Still Exists in Medicine

FRIDAY, Nov. 21, 2014 (HealthDay News) -- Gender inequality still exists in medicine, according to an article published by the American Medical Association (AMA).

More Information

Effect of Interventions to Improve Meds Adherence Vary

FRIDAY, Nov. 21, 2014 (HealthDay News) -- The effects of trials to improve medication adherence are inconsistent, with few studies of the highest quality demonstrating improvement in both adherence and clinical outcome, according to a review published online Nov. 20 in The Cochrane Library.

Abstract
Full Text (subscription or payment may be required)

FDA Approves Abuse-Resistant Extended-Release Hydrocodone

THURSDAY, Nov. 20, 2014 (HealthDay News) -- The U.S. Food and Drug Administration has approved Hysingla ER (hydrocodone bitartrate), an abuse-resistant, extended-release form of hydrocodone.

More Information

Cost of Diabetes Care Keeps Climbing

THURSDAY, Nov. 20, 2014 (HealthDay News) -- The cost of diabetes care in the United States has increased 48 percent in recent years, climbing to more than $322 billion annually, according to research published in the December issue of Diabetes Care.

Full Article
Abstract
Full Text
Editorial

Telephone Reminder Intervention Ups Cardiovascular Rx Adherence

THURSDAY, Nov. 20, 2014 (HealthDay News) -- A low-cost telephone reminder intervention can improve adherence to cardiovascular disease medications, according to a study published online Nov. 16 in the American Journal of Managed Care.

Full Text

Genetic Diversity May Improve Tx Response in Melanoma

THURSDAY, Nov. 20, 2014 (HealthDay News) -- Evidence suggests a genetic basis for clinical response to cytotoxic T-lymphocyte antigen 4 (CTLA-4) blockade in melanoma, according to research published online Nov. 19 in the New England Journal of Medicine.

Abstract
Full Text
Editorial

Mortality Up for Long-Term Opioid Users With Chronic Pain

WEDNESDAY, Nov. 19, 2014 (HealthDay News) -- For adults with chronic noncancer pain, mortality is increased for long-term opioid users, with a smaller increase seen for short-term opioid users and for nonusers versus those without chronic pain, according to a study published in the November issue of PAIN.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Patient-Doc Relationship Affects Alternative Med Use Disclosure

WEDNESDAY, Nov. 19, 2014 (HealthDay News) -- Patient-centered communication with a physician can improve the likelihood of cancer patients disclosing the use of complementary health approaches (CHAs), according to a study published online Nov. 11 in Cancer.

Abstract
Full Text (subscription or payment may be required)

Trainee-Led Time-Outs Can Improve Antimicrobial Use

WEDNESDAY, Nov. 19, 2014 (HealthDay News) -- Trainee-led time-outs to reevaluate antibiotic use can reduce costs in internal medicine units, according to a study published in a supplement to the Nov. 18 issue of the Annals of Internal Medicine, highlighting the Robert Wood Johnson Foundation Clinical Scholars Program.

Full Text (subscription or payment may be required)

Number of Pregnant Women on Opioids Doubles

WEDNESDAY, Nov. 19, 2014 (HealthDay News) -- The proportion of women dependent on drugs such as narcotic painkillers or heroin during pregnancy has more than doubled in the past decade and a half, though it still remains below a half-percent of all pregnancies, according to a study published in the December issue of Anesthesiology.

Full Article
Full Text (subscription or payment may be required)

Low Levels of Vitamin D May Raise Early Death Risk

WEDNESDAY, Nov. 19, 2014 (HealthDay News) -- Having genetically low levels of vitamin D may raise the risk of early death, but the risk is not linked with early death due to cardiovascular-related causes, according to new research published online Nov. 18 in The BMJ.

Full Article
Full Text
Editorial

Parents Want Children in Day Care to Be Vaccinated

TUESDAY, Nov. 18, 2014 (HealthDay News) -- Three-quarters of American parents would consider removing their children from day care if other children did not have all the recommended vaccinations, and many say that under-vaccinated children shouldn't be allowed to attend day care, according to a new University of Michigan C.S. Mott Children's Hospital National Poll on Children's Health.

Full Article
More Information

NSAIDs Tied to Bleeding, Clotting in A-Fib Patients

TUESDAY, Nov. 18, 2014 (HealthDay News) -- Patients with atrial fibrillation who take common analgesics can significantly increase their risk for bleeding and thromboembolism, with risk higher among those on anticoagulation who also take a nonsteroidal anti-inflammatory drug (NSAID), according to a new study published in the Nov. 18 issue of the Annals of Internal Medicine.

Full Article
Full Text (subscription or payment may be required)

Treatments Show Promise in Metastatic Melanoma

TUESDAY, Nov. 18, 2014 (HealthDay News) -- In metastatic melanoma, nivolumab improves overall and progression-free survival versus dacarbazine, and dabrafenib plus trametinib improves survival versus vemurafenib monotherapy, according to two studies published online Nov. 16 in the New England Journal of Medicine.

Abstract 1
Full Text
Abstract 2
Full Text

FDA: Two Generic Versions of ADHD Drug Not As Effective

FRIDAY, Nov. 14, 2014 (HealthDay News) -- Two generic versions of the attention-deficit/hyperactivity disorder drug Concerta may not work as effectively as the brand-name product does, the U.S. Food and Drug Administration said Thursday.

Full Article
More Information

Low Medication Persistence for Older STEMI Patients

FRIDAY, Nov. 14, 2014 (HealthDay News) -- For older patients with non-ST-segment elevation myocardial infarction, evidence-based medication (EBM) persistence is similar after discharge from academic and nonacademic hospitals, according to a study published in the Nov. 15 issue of The American Journal of Cardiology.

Abstract
Full Text (subscription or payment may be required)

Triple Aim Should Be Expanded to Address Physician Burnout

FRIDAY, Nov. 14, 2014 (HealthDay News) -- Expanding the Triple Aim approach -- which includes enhancing patient experience, improving population health, and reducing costs -- to the Quadruple Aim by adding the goal of improving health care provider work life is recommended, according to the authors of an article published in the November/December issue of the Annals of Family Medicine.

Abstract
Full Text

New Rx Regimen Produces HCV SVR in Liver Transplant Patients

FRIDAY, Nov. 14, 2014 (HealthDay News) -- A new drug regimen produced high sustained virologic response (SVR) rates in a small group of liver transplant patients with recurrent hepatitis C virus genotype 1 infection. The report was published online Nov. 12 in the New England Journal of Medicine.

Full Article
Abstract
Full Text (subscription or payment may be required)

Peripheral Nerve Blocks OK for Migraines in Pregnancy

FRIDAY, Nov. 14, 2014 (HealthDay News) -- For migraines that do not respond to medications, peripheral nerve blocks may be a treatment option in pregnant women, according to research published online Nov. 5 in Obstetrics & Gynecology.

Full Text (subscription or payment may be required)

U.S. Prices Soaring for Some Generic Drugs

THURSDAY, Nov. 13, 2014 (HealthDay News) -- Market forces are dramatically driving up the cost of some generic drugs, prompting U.S. investigations into the pricing of what should be cheap alternatives to brand-name medications.

Full Article
Full Text

B Vitamins May Not Boost Cognitive Performance

THURSDAY, Nov. 13, 2014 (HealthDay News) -- Taking vitamin B12 or folic acid supplements may not reduce seniors' risk of memory loss, according to a study published online Nov. 12 in Neurology.

Full Article
Abstract
Full Text (subscription or payment may be required)

High-Intensity Statin Effect Independent of Lipoprotein, CRP

WEDNESDAY, Nov. 12, 2014 (HealthDay News) -- High-intensity statin therapy is associated with coronary atherosclerosis regression, regardless of baseline lipoprotein or C-reactive protein (CRP) levels, according to a study published in the Nov. 15 issue of The American Journal of Cardiology.

Abstract
Full Text (subscription or payment may be required)

Omega-3 PUFAs Can Reduce Smoking, Cut Tobacco Craving

WEDNESDAY, Nov. 12, 2014 (HealthDay News) -- Supplementation with omega-3 polyunsaturated fatty acids (PUFAs) can reduce daily smoking and tobacco craving, according to a study published in the Journal of Psychopharmacology.

Abstract
Full Text (subscription or payment may be required)

Tdap Vaccine Seems Safe in Pregnancy

WEDNESDAY, Nov. 12, 2014 (HealthDay News) -- Getting a tetanus-diphtheria-pertussis (Tdap) vaccine during pregnancy appears safe for the fetus, according to a study published in the Nov. 12 issue of the Journal of the American Medical Association.

Full Article
Abstract
Full Text (subscription or payment may be required)

Patient Preference for Anticoagulant Tx Outcome Varies

WEDNESDAY, Nov. 12, 2014 (HealthDay News) -- Patients' preferences for outcomes of anticoagulation therapy vary and are affected by previous stroke or myocardial infarction experience, according to a study published online Nov. 11 in Circulation: Cardiovascular Quality and Outcomes.

Abstract
Full Text (subscription or payment may be required)

Ezetimibe Not Tied to Higher Cancer Risk, Mortality

WEDNESDAY, Nov. 12, 2014 (HealthDay News) -- Treatment with the lipid-lowering therapy ezetimibe/simvastatin is not associated with an increased risk of developing cancer or an increased risk of dying from cancer, according to research published in the Nov. 15 issue of the American Journal of Cardiology.

Abstract
Full Text (subscription or payment may be required)

Axillary Hair, Deodorant Don't Affect Testosterone Absorption

WEDNESDAY, Nov. 12, 2014 (HealthDay News) -- After application of testosterone solution, serum testosterone concentration is unaffected by the presence or absence of axillary hair or by the use of deodorant/antiperspirant, according to a study published in the November issue of the Journal of Sexual Medicine.

Abstract
Full Text (subscription or payment may be required)

All Vaginal Estrogens Effective for Genitourinary Sx of Menopause

TUESDAY, Nov. 11, 2014 (HealthDay News) -- All vaginal estrogens are effective for women with genitourinary syndrome of menopause, according to a review published online Nov. 5 in Obstetrics & Gynecology.

Full Text (subscription or payment may be required)

Computerized Dashboard Can ID Potentially Inappropriate Meds

TUESDAY, Nov. 11, 2014 (HealthDay News) -- A computerized potentially inappropriate medications (PIMs) dashboard can allow identification of older inpatients on high-risk medication regimens, according to research published online Nov. 3 in the Journal of the American Geriatrics Society.

Abstract
Full Text (subscription or payment may be required)

Evidence Lacking for Widespread Use of β-Blockers in CHD

TUESDAY, Nov. 11, 2014 (HealthDay News) -- There is currently insufficient data to support the use of β-blockers for all patients with clinically stable coronary heart disease (SCHD), according to a paper published in the Nov. 15 issue of The American Journal of Cardiology.

Abstract
Full Text (subscription or payment may be required)

PSA Rise With Testosterone Gel Tied to Specific Factors

TUESDAY, Nov. 11, 2014 (HealthDay News) -- Factors predicting greater prostate-specific antigen (PSA) increases with use of testosterone gel (T-gel) include age 60 years and older, baseline testosterone (T) ≤250 ng/dL, and percentage of free PSA <20 percent, according to a study published in the November issue of the Journal of Sexual Medicine.

Abstract
Full Text (subscription or payment may be required)

Triple Drug Combo Benefits Lupus Nephritis

TUESDAY, Nov. 11, 2014 (HealthDay News) -- In a trial of 368 Chinese patients with lupus nephritis, those who were given a trio of medications were more likely to see a complete remission. The researchers, led by Zhihong Liu, M.D., of the Nanjing University School of Medicine in China, reported the findings online Nov. 11 in the Annals of Internal Medicine.

Full Article
Full Text (subscription or payment may be required)

ACEIs Tied to Lower Risk of Amyotropic Lateral Sclerosis

TUESDAY, Nov. 11, 2014 (HealthDay News) -- Patients who took particular doses of angiotensin-converting enzyme (ACE) inhibitors for more than four years appeared to reduce their risk of developing amyotrophic lateral sclerosis (ALS) by 57 percent, according to new research. The report was published online Nov. 10 in JAMA Neurology.

Full Article
Abstract
Full Text (subscription or payment may be required)

NSAID Use Linked to Increased Risk of Incident A-Fib

MONDAY, Nov. 10, 2014 (HealthDay News) -- Nonsteroidal anti-inflammatory drug (NSAID) use is associated with an increased risk of atrial fibrillation (AF) incidence, particularly among new users, according to a meta-analysis published in the Nov. 15 issue of The American Journal of Cardiology.

Abstract
Full Text (subscription or payment may be required)

Aspirin May Exacerbate Chronic Urticaria in Children

MONDAY, Nov. 10, 2014 (HealthDay News) -- In some children with chronic spontaneous urticaria (CSU), exacerbations may be caused by hypersensitivity to aspirin, according to research published online Oct. 29 in Allergy.

Abstract
Full Text (subscription or payment may be required)

Want to Be a Leader? Cultivate a Healthy Look

FRIDAY, Nov. 7, 2014 (HealthDay News) -- It's more important for potential business or political leaders to look healthy than intelligent, according to a study published online Nov. 5 in Frontiers in Human Neuroscience.

Full Article
Full Text

Predictors of Insomnia ID'd in Long-Term Care Facilities

THURSDAY, Nov. 6, 2014 (HealthDay News) -- Predictors of insomnia in long-term care facilities in Europe and Israel include age, depression, hypnosedatives, and stressful life events, according to a study published online Oct. 30 in the Journal of the American Geriatrics Society.

Abstract
Full Text (subscription or payment may be required)

Lower Doses of Rheumatoid Arthritis Meds May Work for Some

THURSDAY, Nov. 6, 2014 (HealthDay News) -- Some patients in the early stages of rheumatoid arthritis may be able to have their medication doses safely lowered once their symptoms are well under control, according to a study published in the Nov. 6 issue of the New England Journal of Medicine.

Full Article
Full Text (subscription or payment may be required)

More Evidence That Certain NSAIDs Up Post-Stroke Mortality

THURSDAY, Nov. 6, 2014 (HealthDay News) -- Certain cyclooxygenase (COX)-2 inhibitors, including celecoxib (Celebrex) and etodolac (Lodine), are associated with increased mortality within a month after a stroke, according to a study published online Nov. 5 in Neurology.

Full Article
Abstract
Full Text (subscription or payment may be required)

BADGE Exposure Can Elicit Contact Allergy Reactions

THURSDAY, Nov. 6, 2014 (HealthDay News) -- Exposure to aluminum tubes for pharmaceutical use that are internally lacquered with epoxy resins (ER) based on bisphenol A diglycidyl ether (BADGE) can elicit contact allergy reactions, according to a study published online Oct. 29 in Allergy.

Abstract
Full Text (subscription or payment may be required)

Hospital MRSA Traced to U.K. Livestock

WEDNESDAY, Nov. 5, 2014 (HealthDay News) -- A strain of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals can be traced back to livestock, and the strain's resistance to antibiotics is likely due to the widespread use of antibiotics on farms, according to a study published in the December issue of Applied and Environmental Microbiology.

Full Article
Abstract
Full Text

Combo Tx for Advanced Melanoma Found to Up Survival

TUESDAY, Nov. 4, 2014 (HealthDay News) -- Patients with advanced melanoma may live longer when treated with a combination of ipilimumab (Yervoy) and sargramostim, compared to being treated with ipilimumab alone, according to a new study published in the Nov. 5 issue of the Journal of the American Medical Association.

Full Article
Abstract
Full Text (subscription or payment may be required)

Long-Term Shift Work May Drain the Brain

TUESDAY, Nov. 4, 2014 (HealthDay News) -- Working non-standard hours -- "shift work" -- for many years is not only hard on the body, but may also dull the mind, new research suggests. According to the study, published online Nov. 3 in Occupational & Environmental Medicine, those who do shift work for more than 10 years seem to have the equivalent of an extra 6.5 years of age-related decline in memory and thinking skills.

Full Article
Abstract
Full Text (subscription or payment may be required)

Risk of Major Bleeds Up for Dabigatran Versus Warfarin

MONDAY, Nov. 3, 2014 (HealthDay News) -- Dabigatran (Pradaxa) is associated with higher risks of major bleeding and gastrointestinal bleeding compared with warfarin. However, patients taking dabigatran also have a reduced risk of intracranial bleeding compared with those taking warfarin, according to new research published online Nov. 3 in JAMA Internal Medicine.

Full Article
Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

AMA: Absence of Health Insurer Competition in Many Areas

MONDAY, Nov. 3, 2014 (HealthDay News) -- In most metropolitan areas, there is a significant absence of health insurer competition, according to a report published by the American Medical Association (AMA).

More Information

Typical ADHD Care Leaves Room for Improvement

MONDAY, Nov. 3, 2014 (HealthDay News) -- Many community-based pediatricians do not follow guideline-recommended care for children with attention-deficit/hyperactivity disorder (ADHD), according to a new study published online Nov. 3 in Pediatrics.

Full Article
Abstract
Full Text (subscription or payment may be required)


Previous: November 2014 Briefing - Pain Management Next: Hep B Screening Urged for Those Undergoing Chemo, Immune Tx

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion: