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AACR: Genetic Profiling May Optimize Cancer Treatment

Last Updated: April 20, 2009.

Testing for genetic variations may allow clinicians to adjust cancer treatments that optimize progression-free survival, according to several studies presented at the 100th Annual Meeting of the American Association for Cancer Research held from April 18 to 22 in Denver.

MONDAY, April 20 (HealthDay News) -- Testing for genetic variations may allow clinicians to adjust cancer treatments that optimize progression-free survival, according to several studies presented at the 100th Annual Meeting of the American Association for Cancer Research held from April 18 to 22 in Denver.

In one study, Daniel Von Hoff, M.D., from TGen, a non-profit research institute in Phoenix, and colleagues conducted molecular profiling of 66 patients with either refractory ovarian, colorectal, breast, or miscellaneous cancer. After the results suggested a new treatment, improvements in progression-free survival were significantly higher in patients with ovarian, breast, colorectal, and miscellaneous cancer (20 percent, 36 percent, 44 percent, and 16 percent, respectively).

In one of the other studies, researchers suggested that BRAF, PIK3CA and KRAS mutations and loss of PTEN expression impair response to epidermal growth factor receptor-targeted therapies in metastatic colorectal cancer.

"With this trial, we are showing the power of personalized medicine using the tools we already have available to us. As these tools become more precise and more effective, the value of personalized medicine will increase," Von Hoff said in a statement.

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