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Review IDs Gut Microbiota Changes in Irritable Bowel

Last Updated: June 17, 2016.

Patients with irritable bowel syndrome have alterations in their gut microbiota, with distinct alterations for Chinese patients, according to a review and meta-analysis published online June 14 in the Journal of Gastroenterology and Hepatology.

FRIDAY, June 17, 2016 (HealthDay News) -- Patients with irritable bowel syndrome (IBS) have alterations in their gut microbiota, with distinct alterations for Chinese patients, according to a review and meta-analysis published online June 14 in the Journal of Gastroenterology and Hepatology.

Xiaojun Zhuang, from the First Affiliated Hospital of Sun Yat-Sen University in Guangzhou, China, and colleagues conducted a meta-analysis to examine alterations of gut microbiota in IBS patients from China and other regions around the world. Data were included from 10 case-control studies detecting gut microbiota in IBS patients.

The researchers found that the standardized mean differences (SMDs) of Bifidobacteria, Lactobacillus, Escherichia coli, and Enterobacter were −1.42, −0.91, 0.83, and 0.57, respectively, in Chinese patients with IBS compared with healthy controls. No significant differences were seen in the SMDs of Bacteroides and Enterococcus in Chinese patients with IBS. In IBS patients from other regions, the SMDs of Bifidobacteria and Bacteroides were −0.76 and 1.17, respectively, while there were no significant differences in the SMDs of Lactobacillus, Escherichia coli, Enterobacter, and Enterococcus.

"There were alterations of gut microbiota in IBS patients and it implied that alterations of gut microbiota might be involved in the pathogenesis of IBS," the authors write. "However, the species-specific alterations of gut microbiota were different between IBS patients from China and other regions."

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