Vitamin D Linked to Asthma Severity in ChildrenLast Updated: April 27, 2009. Vitamin D insufficiency is present in about one-third of Costa Rican children with asthma and correlates with asthma severity, researchers report in the May 1 issue of the American Journal of Respiratory and Critical Care Medicine.
MONDAY, April 27 (HealthDay News) -- Vitamin D insufficiency is present in about one-third of Costa Rican children with asthma and correlates with asthma severity, researchers report in the May 1 issue of the American Journal of Respiratory and Critical Care Medicine.
John M. Brehm, M.D., from Brigham and Women's Hospital in Boston, and colleagues measured serum 25-hydroxyvitamin D levels and markers of allergy and asthma severity in 616 Costa Rican children with asthma aged 6 to 14 years.
The researchers found that 28 percent of children had insufficient levels of 25-hydroxyvitamin D (less than 30 ng/mL). After adjusting for possible confounding factors, low 25-hydroxyvitamin D levels were associated with high levels of IgE and eosinophils. Each 10-fold increase in 25-hydroxyvitamin D levels was associated with a reduced risk of hospitalization in the previous year (odds ratio, 0.05), use of anti-inflammatory drugs in the previous year (OR, 0.18), and increased methacholine airway responsiveness (OR, 0.15).
"Our results suggest that vitamin D insufficiency is relatively frequent in an equatorial population of children with asthma," Brehm and colleagues conclude.
Authors of the study report financial relationships with the pharmaceutical industry.
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