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Protein Reverses Diabetes-Associated Bone Loss in Mice

Last Updated: April 29, 2009.

Parathyroid hormone-related protein can reverse the bone loss associated with reduced osteoblastic function due to diabetes, according to the results of a study in mice published in the May issue of Endocrinology.

WEDNESDAY, April 29 (HealthDay News) -- Parathyroid hormone-related protein (PTHrP) can reverse the bone loss associated with reduced osteoblastic function due to diabetes, according to the results of a study in mice published in the May issue of Endocrinology.

Daniel Lozano, from Fundacion Jimenez Diaz in Madrid, Spain, and colleagues treated diabetic mice with PTHrP before and after bone marrow ablation.

The researchers found that the diabetic mice had trabecular bone loss and alterations in bone structure, which were reversed by PTHrP treatment. The mice had bone loss in the intact femur and the regenerating tibia after ablation, which was associated with a number of factors including fewer bone-forming cells and reduced matrix mineralization in the case of the tibia. There were also changes in the expression of a number of genes, including PTHrP and the PTH type 1 receptor, the authors report.

"These findings strongly suggest that PTHrP has an important role in the altered osteoblastic function related to diabetes," Lozano and colleagues conclude.

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