Create Account | Sign In: Author or Forum

Search Symptoms

Category: Cardiology | Family Medicine | Internal Medicine | Neurology | Radiology | Journal

Back to Journal Articles

Aggressive Atorvastatin Use Cuts Detectable Inflammation

Last Updated: April 30, 2009.

Aggressive use of atorvastatin therapy over a three-month period produces anti-inflammatory results that can be detected using ultrasmall superparamagnetic iron oxide-enhanced MRI, according to a study published online ahead of print April 29 in the Journal of the American College of Cardiology.

THURSDAY, April 30 (HealthDay News) -- Aggressive use of atorvastatin therapy over a three-month period produces anti-inflammatory results that can be detected using ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI, according to a study published online ahead of print April 29 in the Journal of the American College of Cardiology.

Tjun Y. Tang, of the Cambridge University Hospitals NHS Foundation Trust in the United Kingdom, and colleagues conducted a study of 47 patients with carotid stenosis of more than 40 percent detected using duplex ultrasonography, and intraplaque accumulation detected by USPIO-enhanced MRI. The subjects were randomized to treatment of either 10 mg or 80 mg of atorvastatin a day for 12 weeks and underwent scans at six and 12 weeks.

In each group 20 patients completed the 12-week course of treatment, and at six and 12 weeks the 80-mg group showed a significant reduction in USPIO-defined inflammation, while the low dose did not produce any change, the investigators note. The 80-mg group also showed a total 15 percent reduction in cholesterol and a 29 percent drop in low-density lipoprotein cholesterol, the researchers found.

"This is, to our knowledge, the first study of a targeted MRI contrast agent used in humans to assess therapeutic response in an interventional drug trial," the authors write.

The study was supported by GlaxoSmithKline and several authors disclosed a relationship with the company.

Abstract
Full Text
Editorial


Previous: AAN: Pregabalin Effective for Restless Legs Syndrome Next: WHO Rasies Influenza Epidemic Alert Level From 4 to 5

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion: