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Category: Endocrinology | Monthly Briefing

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December 2016 Briefing - Diabetes & Endocrinology

Last Updated: January 01, 2017.

Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for December 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Aqueous Humor VEGF Levels Up With Prostaglandin for Glaucoma

FRIDAY, Dec. 30, 2016 (HealthDay News) -- Vascular endothelial growth factor (VEGF) levels are significantly higher in the aqueous humor of diabetes mellitus (DM) patients and glaucoma patients who used prostaglandin agents, according to a letter to the editor published online Dec. 23 in Clinical & Experimental Ophthalmology.

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Low Vitamin D Linked to Incident Frailty in Older Women

FRIDAY, Dec. 30, 2016 (HealthDay News) -- For older women, low vitamin D is associated with incident frailty, according to a study published online Dec. 23 in the Journal of the American Geriatrics Society.

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Lactobacillus Supplement Doesn't Impact HbA1c in Type 2 Diabetes

FRIDAY, Dec. 30, 2016 (HealthDay News) -- For patients with type 2 diabetes on insulin therapy, oral supplementation with Lactobacillus reuteri DSM 17938 does not affect glycated hemoglobin (HbA1c), according to a study published online Dec. 23 in Diabetes, Obesity and Metabolism.

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Aflibercept Rescues Vision After Laser for Diabetic Macular Edema

THURSDAY, Dec. 29, 2016 (HealthDay News) -- For eyes experiencing substantial visual loss after macular laser photocoagulation treatment for diabetic macular edema (DME), intravitreal aflibercept improves visual and anatomic outcomes, according to a study published online Dec. 22 in JAMA Ophthalmology.

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Luseogliflozin Effective for T2DM With Low-Carb, High-Carb Diet

THURSDAY, Dec. 29, 2016 (HealthDay News) -- For patients with type 2 diabetes (T2D), the SGLT2 inhibitor luseogliflozin has similar efficacy when meals contain 40 to 55 percent total energy from carbohydrate (TEC), according to a study published online Dec. 19 in Diabetes, Obesity and Metabolism.

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Postprandial Hyperglycemia Linked to CVD Incidence in T2DM

WEDNESDAY, Dec. 28, 2016 (HealthDay News) -- For patients with type 2 diabetes, postprandial hyperglycemia is associated with incidence of cardiovascular disease (CVD) and all-cause mortality, independently of the mean glycated hemoglobin (HbA1c) level, according to a study published online Dec. 15 in the Journal of Diabetes Investigation.

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Personal Health Care Spending Continues to Soar in the U.S.

TUESDAY, Dec. 27, 2016 (HealthDay News) -- From 1996 to 2013 there were considerable increases in personal health care spending in the United States, with the highest amounts for diabetes, ischemic heart disease, and low back and neck pain, according to a study published in the Dec. 27 issue of the Journal of the American Medical Association.

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More Years Lost for Whites Versus South Asians, Blacks With T2DM

TUESDAY, Dec. 27, 2016 (HealthDay News) -- Whites with type 2 diabetes have more life years lost than South Asians or blacks, according to a study published online Dec. 20 in Diabetes Care.

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Chronic Hepatitis B Prevalence Higher in Those With T2DM

FRIDAY, Dec. 23, 2016 (HealthDay News) -- Patients with type 2 diabetes have higher prevalence of chronic hepatitis B virus infection (CHB), according to a study published online Dec. 8 in the Journal of Diabetes Investigation.

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Higher Oxidative Stress Linked to Metabolic Syndrome

THURSDAY, Dec. 22, 2016 (HealthDay News) -- Oxidized low-density lipoprotein (ox-LDL) as a proxy for oxidative stress is associated with metabolic syndrome (MetS) and its components, according to a study published online Dec. 19 in Diabetes.

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Radiation Dose to Head & Neck Tied to Thyroid Dysfunction Risk

WEDNESDAY, Dec. 21, 2016 (HealthDay News) -- For patients with head and neck cancer receiving radiotherapy (RT), thyroid dysfunction is a dose-related complication, with increased risk for female sex and concurrent chemotherapy, according to a study published online Dec. 1 in Head & Neck.

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Serum Biomarker That Reflects Use, Dose of Metformin Identified

WEDNESDAY, Dec. 21, 2016 (HealthDay News) -- The growth differentiation factor 15 (GDF15) is a novel biomarker for the use and dosing of metformin, according to a study published online Dec. 14 in Diabetes Care.

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Higher AlphaB-Crystallin Levels Linked to Diabetic Retinopathy

WEDNESDAY, Dec. 21, 2016 (HealthDay News) -- Vitreous levels of alphaB-crystallin are significantly higher in eyes of patients with proliferative diabetic retinopathy (PDR) compared to the eyes of controls without diabetes, according to a study published online Dec. 7 in Clinical & Experimental Ophthalmology.

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Lowest Glucose Variability for Insulin + GLP-1 RA in T2DM

TUESDAY, Dec. 20, 2016 (HealthDay News) -- For patients with type 2 diabetes, the lowest glucose variability (GV) and hypoglycemia is seen for patients using basal insulin + glucagon-like peptide 1 receptor agonist (GLP-1 RA) (BGLP), according to a study published online Dec. 2 in Diabetes Care.

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Health Care Provider Burnout Negatively Affects Quality, Safety

TUESDAY, Dec. 20, 2016 (HealthDay News) -- Health care provider burnout is negatively associated with quality and safety of health care, according to a meta-analysis published recently in the Journal of General Internal Medicine.

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Guidance on Dietary Sugar Intake Based on Low-Quality Evidence

TUESDAY, Dec. 20, 2016 (HealthDay News) -- Guidelines on dietary sugar intake are of poor quality, and the supporting evidence is of low quality, according to research published online Dec. 20 in the Annals of Internal Medicine.

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DEA Announces Critical Changes in Registration Renewal Process

MONDAY, Dec. 19, 2016 (HealthDay News) -- The Drug Enforcement Administration (DEA) has announced critical changes in its registration renewal process, according to a report published by the American Academy of Family Physicians.

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Noncardiovascular Cause of Death More Common in CHD Patients

MONDAY, Dec. 19, 2016 (HealthDay News) -- For patients with coronary heart disease (CHD), mortality is more often due to noncardiovascular causes, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

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Diabetes Ups Risk of HCC, Death in Patients With Hepatitis C

MONDAY, Dec. 19, 2016 (HealthDay News) -- For hepatitis C virus (HCV)-infected patients, diabetes mellitus (DM) is associated with increased risk of hepatocellular carcinoma (HCC) development and all-cause mortality, according to a study published online Dec. 8 in the Journal of Gastroenterology and Hepatology.

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Long-Term DPP4-Inhibitor Use Not Tied to Fracture Risk in T2DM

MONDAY, Dec. 19, 2016 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM), long-term use of dipeptidyl peptidase-4 inhibitors (DPP4-Is) is not associated with fracture risk, according to a study published online Dec. 10 in Diabetes, Obesity and Metabolism.

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Dysglycemia Affects Brain Structure, Cognition in Seniors

MONDAY, Dec. 19, 2016 (HealthDay News) -- In older adults, dysglycemia is associated with brain structure and cognition, according to a study published online Dec. 5 in the Journal of the American Geriatrics Society.

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No Long-Term Increase in Exercise Levels for Pokémon Go

FRIDAY, Dec. 16, 2016 (HealthDay News) -- Pokémon Go provided a slight, short-term boost to adults' physical activity levels, but it didn't last, according to a study published in the Christmas issue of The BMJ.

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Pioglitazone Improves Whole-Body Aerobic Capacity in MetS

FRIDAY, Dec. 16, 2016 (HealthDay News) -- For adults with metabolic syndrome (MetS), pioglitazone treatment improves whole-body aerobic capacity, according to a study published online Dec. 12 in the Journal of Diabetes Investigation.

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Medical Service Use Down With Deductibles in Diabetes

THURSDAY, Dec. 15, 2016 (HealthDay News) -- Lower-income patients with diabetes and private insurance with a low (LD) or high deductible (HD) have reduced medical service use, according to a study published online Dec. 12 in Diabetes Care.

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Outcomes-Based Pricing Suggested for New, Costly Drugs

WEDNESDAY, Dec. 14, 2016 (HealthDay News) -- Outcomes-based pricing for novel and expensive biopharmaceuticals is supported in an Ideas and Opinions piece published online Dec. 13 in the Annals of Internal Medicine.

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Data-Driven Algorithm Yields Notable Improvements in HbA1c

WEDNESDAY, Dec. 14, 2016 (HealthDay News) -- A data-driven algorithm for personalized diabetes care can yield substantial improvements in hemoglobin A1c (HbA1c), according to a study published online Dec. 5 in Diabetes Care.

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Sliding Scale Insulin Order Sheet Cuts Medication Errors

WEDNESDAY, Dec. 14, 2016 (HealthDay News) -- A standardized sliding scale insulin (SSI) order sheet can reduce the incidence of SSI-related medication errors, according to a study published online Dec. 7 in the Journal of Evaluation in Clinical Practice.

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Risk of Ischemic, Hemorrhagic Stroke Up With Type 1 Diabetes

TUESDAY, Dec. 13, 2016 (HealthDay News) -- The risks of ischemic and hemorrhagic stroke are increased with type 1 diabetes, with incrementally increasing risks with increasing hemoglobin A1c (HbA1c), according to a study published in the November issue of the Journal of Internal Medicine.

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Primary Care Physician Volume Linked to Quality of Diabetes Care

TUESDAY, Dec. 13, 2016 (HealthDay News) -- Primary care physician volume is associated with quality of diabetes care, with lower quality for higher overall volume and higher quality for higher diabetes-specific volume, according to a study published online Dec. 13 in the Annals of Internal Medicine.

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CDC: U.S. Flu Vaccination Rates Low So Far This Season

MONDAY, Dec. 12, 2016 (HealthDay News) -- Only about two out of five Americans had gotten this season's flu vaccination as of early November, the U.S. Centers for Disease Control and Prevention reports.

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Prevalence of Anti-TSH Receptor Antibody High in Fibromyalgia

MONDAY, Dec. 12, 2016 (HealthDay News) -- Patients with fibromyalgia syndrome (FMS) have high prevalence of anti-thyroid-stimulating hormone (TSH) receptor antibody (TRAb), according to a study published online Nov. 30 in the International Journal of Rheumatic Diseases.

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CDC Finds Vaccination Coverage Varies for Adults With Diabetes

MONDAY, Dec. 12, 2016 (HealthDay News) -- Among adults with diagnosed diabetes, vaccination coverage varies, with influenza vaccination more prevalent than pneumococcal or hepatitis B vaccination, according to a December data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Sleep Duration, Efficiency Linked to Inpatient Hyperglycemia

THURSDAY, Dec. 8, 2016 (HealthDay News) -- For hospitalized patients, additional sleep and increased sleep efficiency correlate with lower odds of hyperglycemia and impaired fasting glucose, according to research published online Nov. 30 in Diabetes Care.

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Readings Taken in Clinic May Underestimate Ambulatory BP

WEDNESDAY, Dec. 7, 2016 (HealthDay News) -- Ambulatory blood pressure may be a better indicator of health risks than clinic blood pressure, according to a new report published online Dec. 6 in Circulation.

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Learning Interventions Can Improve Med Student Well-Being

WEDNESDAY, Dec. 7, 2016 (HealthDay News) -- Specific learning interventions may improve emotional well-being among medical students, according to a review published in the Dec. 6 issue of the Journal of the American Medical Association, a theme issue on medical education.

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High Lipoprotein(a) Predicts Cardiac Events in DM With PCI

WEDNESDAY, Dec. 7, 2016 (HealthDay News) -- For patients with diabetes mellitus (DM) undergoing percutaneous coronary intervention (PCI), high lipoprotein(a) (Lp[a]) levels are associated with advanced cardiac events, according to a study published in the Dec. 15 issue of The American Journal of Cardiology.

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Urine Haptoglobin Can Predict Kidney Damage in T2DM

WEDNESDAY, Dec. 7, 2016 (HealthDay News) -- Urine haptoglobin is a novel biomarker for predicting kidney damage in patients with type 2 diabetes (T2D), according to a study published online Nov. 30 in Diabetes Care.

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Prevalence of Disability 2.7 Percent at U.S. Medical Schools

WEDNESDAY, Dec. 7, 2016 (HealthDay News) -- The prevalence of disability is 2.7 percent among medical students at U.S. allopathic medical schools, according to a research letter published in the Dec. 6 issue of the Journal of the American Medical Association, a theme issue of medical education.

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Depression, Suicide Ideation Prevalent in Medical Students

TUESDAY, Dec. 6, 2016 (HealthDay News) -- The prevalences of depression or depressive symptoms and suicide ideation are 27.2 and 11.1 percent, respectively, among medical students, according to a review published in the Dec. 6 issue of the Journal of the American Medical Association, a theme issue on medical education.

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Low Thromboembolism Risk for Contraceptive Use in Diabetes

TUESDAY, Dec. 6, 2016 (HealthDay News) -- For women with diabetes who are using hormonal contraception, the absolute risk of thromboembolism is low, with the lowest rates seen with use of intrauterine and subdermal contraceptives, according to a study published online Nov. 29 in Diabetes Care.

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Clinical Practice Guidelines Cut Pediatric Hospitalizations for DKA

TUESDAY, Dec. 6, 2016 (HealthDay News) -- Implementation of clinical practice guidelines can reduce the length of hospitalizations among children experiencing diabetic ketoacidosis (DKA), according to a study published Nov. 29 in the Journal of Evaluation in Clinical Practice.

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Functionally ID'd Variants in HNF1A Linked to Diabetes Risk

MONDAY, Dec. 5, 2016 (HealthDay News) -- Functionally characterized variants in hepatocyte nuclear factor-1a (HNF1A) genes, which are associated with maturity-onset diabetes of the young (MODY3), are strongly associated with diabetes, according to a study published online Nov. 29 in Diabetes.

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Three Low-Carb Meals a Day Can Lower Insulin Resistance

FRIDAY, Dec. 2, 2016 (HealthDay News) -- Eating low-carbohydrate meals may lead to healthy changes in a woman's metabolism that don't occur when consuming higher-carbohydrate meals, and the timing of exercise may play a role in how beneficial it is for metabolism, according to research published recently in PLOS ONE.

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Delayed Diagnosis for Many Women With PCOS

FRIDAY, Dec. 2, 2016 (HealthDay News) -- Many women diagnosed with polycystic ovary syndrome (PCOS) report delayed diagnosis and receiving inadequate information, according to a study published online Dec. 1 in the Journal of Clinical Endocrinology & Metabolism.

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Incidence of Hospitalization for Hypoglycemia Decreasing

FRIDAY, Dec. 2, 2016 (HealthDay News) -- For patients with type 1 diabetes, the incidence of hospitalization for hypoglycemia (HH) decreased over time in Denmark, with an 8.4 percent annual decrease, according to a study published online Nov. 29 in Diabetes Care.

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Similar Effects for PCSK9, HMGCR Variant-Mediated Lower LDL

FRIDAY, Dec. 2, 2016 (HealthDay News) -- Variants in genes encoding proprotein convertase subtilisin-kexin type 9 (PCSK9) and 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGCR) are associated with almost equivalent effects on the risk of cardiovascular events and diabetes per unit decrease in low-density lipoprotein (LDL) cholesterol level, according to a study published in the Dec. 1 issue of the New England Journal of Medicine.

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AND: Vegetarian Diet a Healthy, Environmentally Sound Choice

THURSDAY, Dec. 1, 2016 (HealthDay News) -- Vegetarian diets are healthy for people of all ages, as well as the environment, according to a new position statement from the Academy of Nutrition and Dietetics (AND). The report has been published in the December issue of the Journal of the Academy of Nutrition and Dietetics.

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Interrupting Sitting Time Ups Blood Glucose Control in T2DM

THURSDAY, Dec. 1, 2016 (HealthDay News) -- For patients with type 2 diabetes, even sitting a bit less might be of real benefit, according to research published online Dec. 1 in Diabetologia.

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CDC: Fewer U.S. Families Struggling to Pay Medical Bills

THURSDAY, Dec. 1, 2016 (HealthDay News) -- The number of people in families having problems paying medical bills fell by nearly 13 million from 2011 through the first six months of 2016, according to a report published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

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Study Supports Smoking Cessation for Smokers of Any Age

THURSDAY, Dec. 1, 2016 (HealthDay News) -- Age at smoking initiation and cessation continue to be important predictors of mortality in U.S. adults over age 70, according to a study published online Nov. 29 in the American Journal of Preventive Medicine.

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