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October 2017 Briefing - Internal Medicine

Last Updated: November 01, 2017.

Here are what the editors at HealthDay consider to be the most important developments in Internal Medicine for October 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Culprit-Lesion-Only PCI Tied to Improved 30-Day Outcomes

TUESDAY, Oct. 31, 2017 (HealthDay News) -- Percutaneous coronary intervention (PCI) of the culprit lesion is associated with better 30-day outcomes than immediate multivessel PCI among patients with multivessel coronary artery disease and acute myocardial infarction with cardiogenic shock, according to a study published online Oct. 30 in the New England Journal of Medicine to coincide with the Cardiovascular Research Foundation Transcatheter Cardiovascular Therapeutics meeting, being held Oct. 29 to Nov. 2 in Denver.

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Systemic Lupus Erythematosus Mortality Down Since 1968

TUESDAY, Oct. 31, 2017 (HealthDay News) -- Rates of systemic lupus erythematosus (SLE) mortality have decreased since 1968 but are still higher than non-SLE mortality, according to a study published online Oct. 30 in the Annals of Internal Medicine.

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Fentanyl or Analogs Tied to More Than Half of All Opioid Deaths

TUESDAY, Oct. 31, 2017 (HealthDay News) -- Fentanyl was involved in more than half of opioid overdose deaths reported in the second half of 2016, according to a study published online Oct. 27 in Morbidity and Mortality Weekly Report.

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Football Career Length, Position Affect White Matter Structure

TUESDAY, Oct. 31, 2017 (HealthDay News) -- For former collegiate and professional football players, career duration and primary playing position appear to modify the effects of concussion history on white matter structure and neural recruitment, according to a study published online Oct. 31 in Radiology.

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Ultrasonography Not Necessary for Evaluation of Hypothyroidism

TUESDAY, Oct. 31, 2017 (HealthDay News) -- Imaging studies, including thyroid ultrasonography, are not required for the evaluation of hypothyroidism, and their risks include treatment of incidentally discovered nodules, patient and physician anxiety, and significant cost, according to a clinical review article published online Oct. 30 in JAMA Internal Medicine.

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Internists Key to Identifying Need for Genetic Counseling for Cancer

TUESDAY, Oct. 31, 2017 (HealthDay News) -- Internists play an important role in identifying which patients may be predisposed to cancer and could benefit from genetic counseling, according to an opinion piece published online Oct. 30 in the Annals of Internal Medicine.

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Depressive Symptoms Increase During Internship Year

TUESDAY, Oct. 31, 2017 (HealthDay News) -- Depressive symptoms increase during the internship year for training physicians, with a greater increase among women, according to a study published online Oct. 30 in JAMA Internal Medicine.

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Ohio Upholds Law Requiring HIV-Infected to Tell Sex Partners

TUESDAY, Oct. 31, 2017 (HealthDay News) -- The Ohio Supreme Court has unanimously upheld the constitutionality of a law requiring HIV-infected individuals to tell their sexual partners of their status before having sex, according to a report published by the Associated Press.

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PFA-100-Measured Aspirin Resistance Linked to CV Events

TUESDAY, Oct. 31, 2017 (HealthDay News) -- Aspirin resistance, measured using the Platelet Function Analyzer (PFA)-100 system, is associated with cardiovascular events in aspirin-treated patients, according to a study published online Oct. 21 in the Journal of Clinical Pharmacy and Therapeutics.

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Diabetes of Exocrine Pancreas Often Classified as T2DM

MONDAY, Oct. 30, 2017 (HealthDay News) -- Diabetes that follows pancreatic disease is frequently classified as type 2 diabetes but is associated with worse glycemic control and higher use of insulin within five years than type 2 diabetes, according to a study published in the August issue of Diabetes Care.

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More Than One in Five U.S. Working Adults Uses Tobacco

MONDAY, Oct. 30, 2017 (HealthDay News) -- Overall, 22.1 percent of working U.S. adults currently use any form of tobacco, according to a study published online Oct. 26 in Morbidity and Mortality Weekly Report.

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Flow Cytometry Assesses Minimal Residual Disease in Myeloma

MONDAY, Oct. 30, 2017 (HealthDay News) -- Data on methods used for assessing minimal residual disease (MRD) in multiple myeloma (MM) are presented in a report published online Oct. 23 in the International Journal of Laboratory Hematology.

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E-Cigarettes Alter Defense Proteins in Airway Secretions

MONDAY, Oct. 30, 2017 (HealthDay News) -- E-cigarette use changes the profile of innate defense proteins in airway secretions, according to a study published online Oct. 20 in the American Journal of Respiratory and Critical Care Medicine.

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Rate of Approval for PCSK9i Therapy 47 Percent

MONDAY, Oct. 30, 2017 (HealthDay News) -- A combination of clinical factors and payer type increase the likelihood of approval for proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) treatment, and rates of approval are low overall, according to a study published online Oct. 30 in Circulation.

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Kidney Damage Seen in Most Patients With Long-Lasting T1D

MONDAY, Oct. 30, 2017 (HealthDay News) -- Most patients with type 1 diabetes (T1D) of long duration have some degree of kidney disease, according to a study published online Oct. 4 in Diabetes Care.

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Treatment for Stage I NSCLC Patients Up From 2000 to 2010

FRIDAY, Oct. 27, 2017 (HealthDay News) -- For patients with stage I non-small-cell lung cancer (NSCLC), the odds of receiving radiation therapy (RT) or surgery increased from 2000 to 2010, with improved survival during the same period, according to a study published online Oct. 26 in the Annals of Thoracic Surgery.

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ERs Contribute Large Portion of Medical Care Delivery

FRIDAY, Oct. 27, 2017 (HealthDay News) -- Emergency departments are increasingly a major source of medical care in the United States, according to a study published online Oct. 17 in the International Journal of Health Services.

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Incretin Tied to Better Outcomes in NOCS-Diabetes

FRIDAY, Oct. 27, 2017 (HealthDay News) -- Incretin treatment appears to improve non-ST-elevation myocardial infarction (NSTEMI) outcomes in patients with type 2 diabetes and non-obstructive coronary artery stenosis (NOCS), according to a study published online Sept. 26 in Diabetes, Obesity and Metabolism.

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Afternoon Heart Surgery Linked to Better Patient Outcomes

FRIDAY, Oct. 27, 2017 (HealthDay News) -- For patients undergoing aortic valve replacement, perioperative myocardial injury occurs more with morning surgery than with afternoon surgery, according to a study published online Oct. 26 in The Lancet.

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Arterial Stiffness Linked to Incidence of Diabetes

FRIDAY, Oct. 27, 2017 (HealthDay News) -- Increased arterial stiffness, as measured by carotid-femoral pulse wave velocity (c-f PWV), is associated with increased incidence of diabetes, according to a study published online Sept. 29 in Diabetes Care.

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Gastric Cancer Incidence Down, Survival Up

FRIDAY, Oct. 27, 2017 (HealthDay News) -- Since 1984, there has been decreased incidence and increased survival rates for gastric cancer (GC), but long-term survival remains low, according to a study published online Oct. 19 in the Journal of Gastroenterology and Hepatology.

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Probiotics Linked to Weight Loss in Obese, Overweight

FRIDAY, Oct. 27, 2017 (HealthDay News) -- Short-term probiotics are associated with reductions in body weight, body mass index (BMI), and fat percentage in overweight or obese subjects, according to research published online Oct. 18 in Obesity Reviews.

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Locus ID'd That Links Comorbid Alcohol Dependence, Depression

THURSDAY, Oct. 26, 2017 (HealthDay News) -- A newly identified genetic risk variant is associated with comorbid alcohol dependence (AD) and major depression (MD) in African Americans, according to a study published online Oct. 25 in JAMA Psychiatry.

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Panel Recommends New Zoster Vaccine as First-Line Treatment

THURSDAY, Oct. 26, 2017 (HealthDay News) -- In a close 8-7 vote, the Advisory Committee on Immunization Practices recommended that Shingrix be chosen over Zostavax as the herpes zoster vaccine of choice in adults aged 50 and older, the Washington Post reported.

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Gifts From Pharma Companies Influence Prescribing Behavior

THURSDAY, Oct. 26, 2017 (HealthDay News) -- Receipt of gifts from pharmaceutical companies is associated with more prescriptions per patient and more costly prescriptions, according to a study published online Oct. 25 in PLOS One.

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HIV Drug Resistance Is Threatening Gains of Treatment

THURSDAY, Oct. 26, 2017 (HealthDay News) -- Resistance to antiretroviral therapy (ART) is threatening the recent gains of treatment in the rate of new HIV infections, according to a perspective article published online Oct. 25 in the New England Journal of Medicine.

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Chewing Ticagrelor Loading Dose May Be Beneficial in STEMI

THURSDAY, Oct. 26, 2017 (HealthDay News) -- For patients with ST-segment elevation myocardial infarction (STEMI), chewing a loading dose (LD) of ticagrelor facilitates better early platelet inhibition, according to a study published online Oct. 25 in JAMA Cardiology.

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Detectable Levels of Roundup Ingredient Rising in Older Adults

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Detectable levels of glyphosate, the primary ingredient in the herbicide Roundup, have significantly increased in older adults over time, according to a research letter published online Oct. 24 in the Journal of the American Medical Association.

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Most Patients Satisfied With Relationship With Physician

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Results of the Physicians Foundation 2017 Patient Survey show that most patients are satisfied with their overall relationship with their physician, according to an article published by the American Academy of Family Physicians.

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Alterations in Gut Microbiome Noted Within 72 Hours of Injury

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Critically injured patients develop changes in the composition of the gut microbiome within 72 hours, according to a study published online Oct. 23 in Trauma Surgery & Acute Care Open.

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Researchers Study Mediating Role of Leptin in Bulimia

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Leptin appears to mediate the correlation between weight suppression (WS) and duration of illness in bulimia nervosa-syndrome (BN-S), according to a study published online Oct. 16 in the International Journal of Eating Disorders.

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Module Developed to Improve Adult Vaccination Rates

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- A module has been developed to help health care professionals improve vaccination rates among adults, according to an article published by the American Medical Association (AMA).

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New Clinical Practice Guideline for Management of T2DM

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Management of type 2 diabetes should include shared decision making, and patients should be offered individualized diabetes self-management education and glycemic management plans, according to a summary of a clinical practice guideline published online Oct. 23 in the Annals of Internal Medicine.

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Undiagnosed Diabetes Accounts for Small Portion of Diabetes

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Undiagnosed diabetes accounts for a relatively small proportion of the total diabetes population in the United States, according to a study published online Oct. 23 in the Annals of Internal Medicine.

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Diabetes Tied to Worse Outcomes in Heart Failure Patients

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Among patients with acute heart failure (HF), long-term prognosis is worse in those who have diabetes than in those who do not, though prognosis has improved in both groups, according to a study published online Oct. 5 in Diabetes Care.

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Vitamin D Supplements Improve Markers of Bone Turnover in CKD

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- For patients with chronic kidney disease (CKD), cholecalciferol supplementation can correct vitamin D deficiency and improve markers of bone turnover, according to a study published online Oct. 17 in the Journal of Bone and Mineral Research.

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Secondary Prevention Meds Often Not Started Post-AMI in Seniors

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Thirty-seven percent of older nursing home (NH) residents do not initiate secondary prevention medications after acute myocardial infarction (AMI), according to a study published online Oct. 17 in the Journal of the American Geriatrics Society.

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AMA Addresses Physicians' Role in Addressing Unsafe Water

TUESDAY, Oct. 24, 2017 (HealthDay News) -- Clinicians should be trained to recognize symptoms of contaminated water use in order to help prevent contamination and execute other public health duties, according to an American Medical Association (AMA) report about the October issue of the AMA Journal of Ethics.

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DEA Taking Back Unwanted Prescription Drugs on Oct. 28

TUESDAY, Oct. 24, 2017 (HealthDay News) -- The public is being given its 14th opportunity to safely dispose of pills and patches at collection points operated by the U.S. Drug Enforcement Agency (DEA) and its partners.

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Swedish Massage May Reduce Cancer-Related Fatigue

TUESDAY, Oct. 24, 2017 (HealthDay News) -- Swedish massage therapy (SMT) is associated with clinically significant relief from cancer-related fatigue (CRF) in breast cancer survivors, according to a study published online Oct. 17 in Cancer.

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Proper Training Key for Primary Care Medical Assistants

TUESDAY, Oct. 24, 2017 (HealthDay News) -- Qualified medical assistants can help primary care practices become more efficient, reduce patient wait times, and streamline patient processing, but their training may be lacking, according to an article published online Oct. 10 in Medical Economics.

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Very High Exercise Levels May Up CAC Risk in White Males

TUESDAY, Oct. 24, 2017 (HealthDay News) -- White males who participate in three times the recommended physical activity (PA) guidelines over many years have higher odds of developing coronary subclinical atherosclerosis by middle age, according to a study published online Oct. 16 in Mayo Clinic Proceedings.

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High Dietary Fiber Protects Against Femoral Neck Bone Loss

TUESDAY, Oct. 24, 2017 (HealthDay News) -- Higher dietary total fiber and fruit fiber is protective against bone loss at the femoral neck in men, according to a study published online Oct. 12 in the Journal of Bone and Mineral Research.

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Most in U.S. Don't Agree That Household Guns Up Suicide Risk

TUESDAY, Oct. 24, 2017 (HealthDay News) -- Most U.S. adults do not agree that household firearms increase the risk of suicide, according to a research letter published online Oct. 23 in the Annals of Internal Medicine.

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Inverse Association Seen for Coffee Drinking, Markers of CVD

TUESDAY, Oct. 24, 2017 (HealthDay News) -- There appears to be an inverse association between coffee intake and protein markers linked to cardiovascular disease, according to a study published online Oct. 16 in the Journal of Internal Medicine.

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Aerobics May Benefit Platelet Reactivity in Menopausal Women

TUESDAY, Oct. 24, 2017 (HealthDay News) -- Regular aerobic exercise may improve regulation of platelet reactivity, providing a cardioprotective effect, in pre- and postmenopausal women, according to a small study published online Oct. 12 in the Journal of Thrombosis and Haemostasis.

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Tofogliflozin Most Effective With High Baseline Insulin

TUESDAY, Oct. 24, 2017 (HealthDay News) -- The sodium glucose co-transporter 2 inhibitor tofogliflozin is effective for reducing fasting plasma glucose and body weight, particularly in patients with a high insulin level at baseline, according to a study published online Oct. 15 in the Journal of Diabetes Investigation.

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Statins May Raise Odds of T2DM in Those at High Risk

TUESDAY, Oct. 24, 2017 (HealthDay News) -- For populations at high-risk for diabetes, statin use is associated with increased risk of developing diabetes, according to a study published online Oct. 23 in BMJ Open Diabetes Research & Care.

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Medicaid's Best-Price Rule May Not Be Such a Big Problem

MONDAY, Oct. 23, 2017 (HealthDay News) -- Medicaid's best-price rule is not as serious a problem as drug manufacturers imply, although it may affect novel pricing arrangements, according to an article published online Sept. 28 in the Journal of Health Politics, Policy and Law.

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Design Thinking Enables Med Students to Solve Challenges

MONDAY, Oct. 23, 2017 (HealthDay News) -- A joint effort between students at Warren Alpert Medical School of Brown University and Rhode Island School of Design (RISD) is training future physicians in design thinking to help identify and repair health system issues that contribute to physician burnout, according to an article by the American Medical Association.

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Sudden Death Most Common CV Death in T2DM/ASCVD

MONDAY, Oct. 23, 2017 (HealthDay News) -- Among patients with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD), sudden death is the most common category of cardiovascular (CV) mortality, according to a study published online Oct. 6 in Diabetes Care.

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Smoking Alters Genetic Relationship with Parkinson's

MONDAY, Oct. 23, 2017 (HealthDay News) -- Smoking may modify a previously reported genetic association with Parkinson's disease (PD), according to an analysis published online Oct. 5 in the Annals of Neurology.

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2003 to 2014 Saw Drop in Urinary Arsenic in Public Water Users

MONDAY, Oct. 23, 2017 (HealthDay News) -- From 2003 to 2014, urinary arsenic decreased among users of public water systems but not among private well users, according to a study published online Oct. 22 in the The Lancet Public Health.

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Psychosocial Intervention May Boost Hospitalization Satisfaction

MONDAY, Oct. 23, 2017 (HealthDay News) -- A brief psychosocial intervention in which physicians ask inpatients about their current situation and respond empathetically appears to improve the hospitalization experience, according to a study published in the October issue of Family Medicine.

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Less Sedentary Time May Attenuate Genetic Role in Obesity

MONDAY, Oct. 23, 2017 (HealthDay News) -- Interactions between genes and physical activity and genes and sedentary behavior may play a role in the development of obesity, according to a study published in the October issue of Diabetes.

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Leukemia Patients Who Survive Severe GVHD Often Fare Worse

MONDAY, Oct. 23, 2017 (HealthDay News) -- After hematopoietic stem cell transplantation (HSCT) for acute leukemia, patients who survive severe acute graft-versus-host disease (aGVHD) have a higher risk of developing extensive chronic GVHD (cGVHD) and a higher rate of non-relapse mortality compared with those who did not develop severe aGVHD, according to a study published online Oct. 13 in the Journal of Internal Medicine.

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Alcoholic Cirrhosis Linked to Increased Admissions, Costs

FRIDAY, Oct. 20, 2017 (HealthDay News) -- Compared with patients who have non-alcoholic cirrhosis, those with alcoholic cirrhosis are sicker at presentation, have more admissions and readmissions, and have nearly double the health care costs, according to a study scheduled for presentation at The Liver Meeting, being held by the American Association for the Study of Liver Diseases from Oct. 20 to 24 in Washington, D.C.

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Herbal and Dietary Supplements Are Commonly Mislabeled

FRIDAY, Oct. 20, 2017 (HealthDay News) -- Mislabeling of herbal and dietary supplements (HDS) is common, occurring in more than half of products tested, according to a study scheduled for presentation at The Liver Meeting, being held by the American Association for the Study of Liver Diseases from Oct. 20 to 24 in Washington, D.C.

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Clinician Job Satisfaction Linked to Improved Burnout Scores

FRIDAY, Oct. 20, 2017 (HealthDay News) -- Clinicians' job satisfaction is associated with improved burnout scores and reduced intention to leave their practices, according to a study published in the October issue of Health Affairs.

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H7N9 Avian Influenza May Be Capable of Pandemic

FRIDAY, Oct. 20, 2017 (HealthDay News) -- A highly pathogenic H7N9 avian influenza variant has evolved and now has the potential to cause a pandemic, according to a study published online Oct. 19 in Cell Host & Microbe.

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Independent Pharmacies Adding Patient Care Services, Products

FRIDAY, Oct. 20, 2017 (HealthDay News) -- Independent pharmacies are expanding the scope of services they offer, partly to absorb lower reimbursements for dispensing prescription medications, according to the 2017 National Community Pharmacists Association (NCPA) Digest.

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For Hepatitis B Patients, Aspirin Tied to Lower Risk of HCC

FRIDAY, Oct. 20, 2017 (HealthDay News) -- Aspirin therapy is associated with a reduced risk of hepatitis B virus-related hepatocellular carcinoma (HCC), according to a study scheduled for presentation at The Liver Meeting, held by the American Association for the Study of Liver Diseases from Oct. 20 to 24 in Washington, D.C.

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Oncogenic Oral HPV DNA Detected in 3.5 Percent of Adults

FRIDAY, Oct. 20, 2017 (HealthDay News) -- Men have a higher prevalence of oncogenic oral human papillomavirus (HPV) than women, and prevalence increases with the number of lifetime oral sexual partners and tobacco use, according to a study published online Oct. 19 in the Annals of Oncology.

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Conditions Tied to Clinician Dissatisfaction Are Modifiable

THURSDAY, Oct. 19, 2017 (HealthDay News) -- Modifiable conditions, like chaos, incohesiveness, and lack of communication, contribute to unsatisfying workplaces for clinicians, according to a study published in the October issue of Health Affairs.

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Diabetes Ups Risk of MACE in Acute Coronary Syndromes

THURSDAY, Oct. 19, 2017 (HealthDay News) -- For patients with acute coronary syndromes (ACS), diabetes mellitus (DM), but not pre-DM, is associated with an increased risk of major adverse cardiac events (MACE), according to a study published online Oct. 18 in the Journal of the American College of Cardiology.

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Uninsurance Down by One-Third for Cancer Diagnoses in 2014

THURSDAY, Oct. 19, 2017 (HealthDay News) -- In the first year of the Affordable Care Act (ACA), there was a relative decrease of one-third in uninsurance among adults with new cancer diagnoses, according to a research letter published online Oct. 19 in JAMA Oncology.

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MACE Risk Similar for White Men, Women, Minorities After PCI

THURSDAY, Oct. 19, 2017 (HealthDay News) -- Women and minorities undergoing percutaneous coronary intervention (PCI) with everolimus-eluting stents have a risk of major adverse cardiac events (MACE) that is similar to that of white men, according to a study published online Oct. 18 in JAMA Cardiology.

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More Penalties With Hospital-Wide Readmission Measure

THURSDAY, Oct. 19, 2017 (HealthDay News) -- Transition from a condition-specific to a hospital-wide readmission measure would result in a modest increase in the number of hospitals eligible for readmission penalties and would substantially increase penalties for safety-net hospitals, according to a study published online Oct. 18 in the New England Journal of Medicine.

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Tofacitinib Superior to Placebo in Active Psoriatic Arthritis

THURSDAY, Oct. 19, 2017 (HealthDay News) -- For patients with active psoriatic arthritis who have an inadequate response to tumor necrosis factor (TNF) inhibitors or to conventional synthetic disease-modifying antirheumatic drugs (DMARDs), tofacitinib is superior to placebo, according to two studies published online Oct. 18 in the New England Journal of Medicine.

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Key Stakeholders Discuss How to Make EHRs More Usable

THURSDAY, Oct. 19, 2017 (HealthDay News) -- Key stakeholders and physicians discussed electronic health record (EHR) usability and optimization in the American Medical Association Running Your Practice Community.

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MRI Findings Prognostic for Long-Term Recovery in Cardiac Arrest

THURSDAY, Oct. 19, 2017 (HealthDay News) -- Measures of cerebral functional network connectivity measured within four weeks of cardiac arrest (CA) are associated with a favorable outcome (FO) at one year, according to a study published online Oct. 18 in Radiology.

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IV Prochlorperazine Beats IV Hydromorphone for Migraine

THURSDAY, Oct. 19, 2017 (HealthDay News) -- Intravenous (IV) hydromorphone is less effective than IV prochlorperazine plus diphenhydramine for acute migraine treatment in the emergency department, according to a study published online Oct. 18 in Neurology.

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New Expert Consensus Pathway for Mitral Regurgitation

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Identification of mitral regurgitation (MR) should prompt evaluation of its etiology, mechanism, severity, and indications for treatment, according to an expert consensus decision pathway published online Oct. 18 in the Journal of the American College of Cardiology.

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Extended-Release Naltrexone Promising for Opioid Dependence

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Extended-release naltrexone is noninferior to buprenorphine-naloxone for maintaining short-term abstinence from heroin and other illicit substances, according to a study published online Oct. 18 in JAMA Psychiatry.

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Sharing Passwords Is Widespread Among Medical Staff

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Sharing of passwords to access electronic medical records is common among medical staff members, according to a study published in the July issue of Healthcare Informatics Research.

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PPI Use Linked to Increased Risk of Ischemic Stroke, MI

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Proton pump inhibitor (PPI) use is associated with increased risk of first-time ischemic stroke and myocardial infarction (MI), according to a study published online Oct. 12 in the Journal of Internal Medicine.

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Lifestyle, Metformin Interventions Have Variable Effects

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- For individuals with impaired glucose regulation, the impact of lifestyle and metformin interventions vary for progression to diabetes mellitus (DM) and likelihood of regression to normal glucose regulation (NGR), according to a study published online Oct. 11 in Diabetes Care.

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Clinical Evidence Synopsis Published for T2DM

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Adding a sulfonylurea or metformin to insulin is associated with approximately a 1 percent reduction in hemoglobin A1c (HbA1c), and addition of a sulfonylurea (but not metformin) is associated with more hypoglycemic events, according a clinical evidence synopsis published online Oct. 17 in the Journal of the American Medical Association.

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Pre-Exposure Prophylaxis for Homosexual Men Cost-Effective

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Introduction of an HIV pre-exposure prophylaxis (PrEP) program for men who have sex with men (MSM) in the United Kingdom is likely to be cost-effective, according to a study published online Oct. 17 in the The Lancet Infectious Diseases.

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Visceral Adipose Tissue Index IDs Risk of HCC in Cirrhosis

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- For male patients with cirrhosis, visceral adipose tissue index (VATI) is an independent risk factor for hepatocellular carcinoma (HCC), according to a study published online Oct. 10 in Hepatology.

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No Increased Risks for DOAC Use Versus Warfarin in VTE

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- For patients with venous thromboembolism, direct oral anticoagulant (DOAC) use is not associated with increased risk of major bleeding or mortality within the first 90 days compared with warfarin use, according to a study published online Oct. 17 in the BMJ.

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Men Now Comprise ~10 Percent of RN Workforce

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- The increasing participation of men in registered nursing can be attributed to multiple factors, including increasing educational attainment, rising labor demand in health care, and liberalizing gender role attitudes, according to a working paper published by the Washington Center for Equitable Growth.

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Overall Survival Up for Melanoma Brain Metastases

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Overall survival (OS) for patients with melanoma brain metastases (MBM) has improved significantly since 2000, according to a study published online Oct. 12 in Cancer.

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Tau May Predict Neurological Outcome After Cardiac Arrest

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Serum tau is a promising novel biomarker for prediction of neurological outcome in patients with cardiac arrest, according to a study published online Oct. 5 in the Annals of Neurology.

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Glycemic Control Up With Oral Semaglutide in Type 2 Diabetes

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Oral semaglutide is associated with better glycemic control than placebo among type 2 diabetes patients with insufficient glycemic control, according to a study published online Oct. 17 in the Journal of the American Medical Association.

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Machine Learning Model Predicts Risk of Upgrade to Breast CA

TUESDAY, Oct. 17, 2017 (HealthDay News) -- A machine learning model can predict the risk of upgrade of high-risk breast lesions (HRLs) to cancer, according to a study published online Oct. 17 in Radiology.

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Doctors Urged to Speak With Patients About Firearms

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Physicians should make a public commitment to speak with their patients about firearms, according to an opinion piece published online Oct. 16 in the Annals of Internal Medicine.

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Mortality Up for Male Recipients of Blood From Ever-Pregnant

TUESDAY, Oct. 17, 2017 (HealthDay News) -- For males, receipt of a red blood cell transfusion from an ever-pregnant female is associated with increased rate of all-cause mortality compared with a male donor, according to a study published online Oct. 17 in the Journal of the American Medical Association.

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Potentially Preventable Spending Concentrated in Frail Elderly

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Much of the total potentially preventable spending for Medicare beneficiaries is concentrated among frail elderly individuals, according to a study published online Oct. 16 in the Annals of Internal Medicine.

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Thrombosis Odds Up With Bioresorbable Vascular Scaffolds

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Everolimus-eluting bioresorbable vascular scaffolds (BVSs) are associated with increased odds of scaffold thrombosis and other thrombotic events compared with everolimus-eluting metallic stents (EESs), according to a review published online Oct. 16 in the Annals of Internal Medicine.

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Commercial Weight Management Program May Help Prevent T2D

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Primary care referral along with a commercial weight management provider can deliver an effective diabetes prevention program (DPP), according to a study published online Oct. 16 in BMJ Open Diabetes Research & Care.

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Prevalence of Oral HPV Infection Higher for U.S. Men

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Oral human papillomavirus (HPV) infection and high-risk oral HPV infection are more common among men than women, according to a study published online Oct. 16 in the Annals of Internal Medicine.

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Female Physicians May Be Especially at Risk of Burnout

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Female physicians are more burned out than their male colleagues, but there are steps they can take to reduce the stress associated with burnout, according to a blog post published in Medical Economics.

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Ketamine Not Linked to PTSD in Military Trauma Setting

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Ketamine administration is not associated with post-traumatic stress disorder (PTSD) in the military trauma setting, according to a study published online Oct. 3 in Anaesthesia.

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Screening Tools Identify Potentially Inappropriate Meds

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Internal medicine patients are frequently prescribed potentially inappropriate medications (PIMs), but screening tools can detect clinically relevant PIMs, according to a study published online Oct. 8 in the Journal of Clinical Pharmacy and Therapeutics.

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'Liquid Biopsy' Shows Promise for Hepatocellular Carcinoma

TUESDAY, Oct. 17, 2017 (HealthDay News) -- 'Liquid biopsy' technology holds promise for diagnosing, monitoring, and predicting prognosis in patients with hepatocellular carcinoma (HCC), according to a study published online Oct. 9 in Nature Materials.

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Venovenous Hemodiafiltration Improves Metformin Toxicity

TUESDAY, Oct. 17, 2017 (HealthDay News) -- High-volume continuous venovenous hemodiafiltration (CVVH) and resin-sorbent hemoperfusion is effective for eliminating metformin, according to a case study published online Oct. 5 in the Journal of Diabetes Investigation.

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Gastric Acid Suppression May Promote Liver Injury

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Based on data from mouse models and humans, a decrease in gastric acid secretion due to use of gastric acid suppressive medications seems to promote overgrowth of intestinal Enterococcus, which promotes liver disease, according to a study published online Oct. 10 in Nature Communications.

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Kneeling Posture Impacts Chest Compressions' Effectiveness

MONDAY, Oct. 16, 2017 (HealthDay News) -- During cardiopulmonary resuscitation (CPR) performed by males, self-adjusted and nearest kneeling postures are more effective for chest compression, with lower perceived exertion, according to a study published online Oct. 5 in the Journal of Clinical Nursing.

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U.S. M.D. Graduates Make Up Half of New Family Medicine Residents

MONDAY, Oct. 16, 2017 (HealthDay News) -- U.S. M.D. graduates make up half the entering first-year class of family medicine residencies, and the increase in postgraduate year 1 (PGY-1) family medicine and primary care positions is lagging behind that of non-primary care specialties, according to two studies published in the October issue of Family Medicine.

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Online Ratings Not Aligned With Objective Quality Measures

MONDAY, Oct. 16, 2017 (HealthDay News) -- Online consumer ratings of specialist physicians do not predict objective measures of quality of care or peer assessment of clinical performance, according to a study published online Sept. 8 in the Journal of the American Medical Informatics Association.

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Most Female Physicians Have Faced Sexist Patient Comments

MONDAY, Oct. 16, 2017 (HealthDay News) -- Most female physicians have been sexually harassed by patients at some point in their careers, according to a blog post published in Medical Economics.

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Worse HIV Care Outcomes for Hispanics, Latinos

MONDAY, Oct. 16, 2017 (HealthDay News) -- HIV care outcomes are worse for Hispanics and Latinos, especially for injection drug users, according to a study published online Oct. 12 in Morbidity and Mortality Weekly Report.

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Bright White Light Therapy Promising for Bipolar Depression

MONDAY, Oct. 16, 2017 (HealthDay News) -- Midday bright light therapy may be effective for treating bipolar depression, according to a study published online Oct. 3 in The American Journal of Psychiatry.

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New Screening Tool Can Identify Diabetic Retinopathy

MONDAY, Oct. 16, 2017 (HealthDay News) -- A new screening tool can adequately detect risk of diabetic retinopathy in adults with diabetes in low-income communities in Mexico, according to a study published in the October issue of Preventing Chronic Disease.

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Many College Students Believe Stimulants Can Boost Grades

MONDAY, Oct. 16, 2017 (HealthDay News) -- More than one-quarter of college students report believing that nonmedical use of prescription stimulants (NPS) can improve academic performance, according to a study published in the January 2018 issue of Addictive Behaviors.

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Moderate Alcohol Consumption Tied to Lower Heart Failure Risk

MONDAY, Oct. 16, 2017 (HealthDay News) -- Moderate alcohol consumption is associated with reduced risk of heart failure but not atrial fibrillation (AF), according to a study published online Oct. 11 in JACC: Heart Failure.

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Model Predicts Cost-Effectiveness for Anal Lesion Treatment

MONDAY, Oct. 16, 2017 (HealthDay News) -- Cost-effective management of precancerous anal intraepithelial lesions in HIV-positive men who have sex with men (MSM) varies by age, according to a study published online Sept. 26 in Cancer.

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