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Influenza, Some Viral URIs Increase Risk of Acute MI

Last Updated: January 24, 2018.

Certain respiratory infections, especially influenza, are associated with an increased risk of acute myocardial infarction during the first seven days after respiratory specimen collection, according to a study published in the Jan. 25 issue of the New England Journal of Medicine.

WEDNESDAY, Jan. 24, 2018 (HealthDay News) -- Certain respiratory infections, especially influenza, are associated with an increased risk of acute myocardial infarction during the first seven days after respiratory specimen collection, according to a study published in the Jan. 25 issue of the New England Journal of Medicine.

Jeffrey C. Kwong, M.D., from the Institute for Clinical Evaluative Sciences in Toronto, and colleagues used a self-controlled case-series design to examine the correlation between laboratory-confirmed influenza infection and hospitalization for acute myocardial infarction. High-specificity laboratory methods were used to confirm influenza infection in respiratory specimens, and hospitalization for acute myocardial infarction was ascertained from administrative data.

The researchers identified 364 hospitalizations for acute myocardial infarction that occurred within one year before and one year after a positive influenza test. Twenty of these occurred during the risk interval (first seven days after respiratory specimen collection) and 344 occurred during the control interval (one year before and one year after the risk interval). The incidence ratio was 6.05 for admission for acute myocardial infarction during the risk interval versus the control interval. After day seven there was no increased incidence. The incidence ratios were 10.11, 5.17, 3.51, and 2.77 for acute myocardial infarction within seven days of detection of influenza B, influenza A, respiratory syncytial virus, and other viruses, respectively.

"We found a significant association between respiratory infections, especially influenza, and acute myocardial infarction," the authors write.

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