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Approach Offers Regional Control of HPV-Related Head, Neck CA

Last Updated: February 09, 2018.

Good regional control can be achieved with up-front surgery and adjuvant therapy for patients with invasive nodal disease from oropharyngeal squamous cell carcinoma related to human papillomavirus, according to a study published online Jan. 29 in Head & Neck.

FRIDAY, Feb. 9, 2018 (HealthDay News) -- Good regional control can be achieved with up-front surgery and adjuvant therapy for patients with invasive nodal disease from oropharyngeal squamous cell carcinoma (SCC) related to human papillomavirus (HPV), according to a study published online Jan. 29 in Head & Neck.

Joseph Zenga, M.D., from Washington University in Saint Louis, and colleagues assessed oncologic outcomes among 72 patients with HPV-related oropharyngeal SCC requiring resection of major muscular or neurovascular tissue during neck dissection for invasive nodal disease.

The researchers found that regional recurrences were seen in 6 percent of patients, and 17 percent experienced distant recurrences. Decreased disease-free survival was associated with advanced T classification, pathological node number ≥5, and omission of adjuvant therapy. However, adding adjuvant chemotherapy did not improve survival.

"In patients with HPV-related oropharyngeal SCC requiring resection of major muscular or neurovascular tissue due to invasive nodal disease, up-front surgical management with adjuvant therapy results in excellent long-term regional control," the authors write.

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