Study Explores Genetic Links to Crohn’s ComplicationsLast Updated: September 18, 2009. Genetic polymorphisms may be associated with risk of certain complications in individuals with Crohn's disease, according to research published in the September issue of Clinical Gastroenterology and Hepatology.
FRIDAY, Sept. 18 (HealthDay News) -- Genetic polymorphisms may be associated with risk of certain complications in individuals with Crohn's disease, according to research published in the September issue of Clinical Gastroenterology and Hepatology.
Liesbet Henckaerts, M.D., of the Catholic University of Leuven in Belgium, and colleagues analyzed data from 875 patients with Crohn's disease. The researchers genotyped 50 single nucleotide polymorphisms to assess possible relationships between genetic variants and several Crohn's disease-related outcomes.
The researchers found that homozygosity for the minor G-allele at rs1363670 in the AK097548 gene was significantly associated with stricturing disease behavior (odds ratio, 5.48), as well as shorter time to stricture. A higher risk of perianal fistula was associated with a C-allele at the CDKAL1 single nucleotide polymorphism rs6908425 (odds ratio, 8.86), with a shorter time to first development in smokers and those with colonic involvement. The absence of NOD2 variants was also independently associated with the development of perianal fistula (odds ratio, 0.56).
"In conclusion, the results of our study confirm the hypothesis that genetic polymorphisms play a role in susceptibility for some complications in Crohn's disease patients, and that they might help in risk stratification of patients at or around time of diagnosis," the authors write. "Crohn's disease-associated polymorphisms play a role in disease progression and might be useful in identifying patients who could benefit from an early top-down treatment approach."
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