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Efficacy of Treatments for Overactive Bladder Examined

Last Updated: September 30, 2009.

Sacral nerve stimulation and botulinum toxin are effective treatments for overactive bladder, according to two studies in the October issue of the Journal of Urology.

WEDNESDAY, Sept. 30 (HealthDay News) -- Sacral nerve stimulation and botulinum toxin are effective treatments for overactive bladder, according to two studies in the October issue of the Journal of Urology.

In the first study, Wesley M. White, M.D., and colleagues from the University of Tennessee Medical Center in Knoxville compared outcomes after sacral nerve stimulation in 19 elderly females (70 years or older) and 170 younger patients with refractory overactive bladder. They found that both groups had a similar rate of successful conversion (89.5 and 97.1 percent, respectively) and adverse events, although elderly patients were significantly more likely to undergo removal of an implantable pulse generator.

In the second study, Antonella Giannantoni, M.D., from the University of Perugia in Italy, and colleagues injected botulinum toxin type A into the detrusor muscle of four patients with Parkinson's disease and two patients with multiple system atrophy who had refractory overactive bladder symptoms and detrusor overactivity. They found that the subjects had reduced daytime and nighttime urinary frequency, improved quality of life, and improved urinary function without systemic side effects.

"The new beneficial effect that we report in a small study sample encourages larger trials to confirm botulinum toxin type A injection into the detrusor muscle as an effective and safe treatment for refractory overactive bladder symptoms and detrusor overactivity related to Parkinson's disease and multiple system atrophy," Giannantoni and colleagues conclude.

Abstract - White
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Abstract - Giannantoni
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