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Brain Seems to Play Role in Resveratrol’s Diabetes Effect

Last Updated: October 12, 2009.

Resveratrol appears to exert an anti-diabetic effect in mice via the brain, with intracerebroventricular treatment improving hyperglycemia and hyperinsulinemia, according to research published online Oct. 9 in Endocrinology.

MONDAY, Oct. 12 (HealthDay News) -- Resveratrol appears to exert an anti-diabetic effect in mice via the brain, with intracerebroventricular treatment improving hyperglycemia and hyperinsulinemia, according to research published online Oct. 9 in Endocrinology.

Giorgio Ramadori, Ph.D., of the University of Texas Southwestern Medical Center in Dallas, and colleagues analyzed data from mice that were given regular chow and left untreated, mice given a high-calorie diet and treated with intracerebroventricular saline infusion, or mice fed a high-calorie diet and treated with intracerebroventricular resveratrol.

After five weeks of treatment, the researchers found that both groups of infused mice -- which were similarly obese before surgery -- stayed equally overweight compared to chow-fed mice. The treated groups had similar food intake following surgery. Resveratrol-treated mice had normalization of their hyperglycemia, and near-normalization of hyperinsulinemia. Findings also suggested that the resveratrol reduced inflammation in the brains of the mice, and possibly improved liver glucose production.

"In conclusion, we identified the brain as a key site for mediating resveratrol anti-diabetic actions. We found that CNS [central nervous system] resveratrol delivery improves diet-induced brain inflammation, a mechanism we speculate contributes to the improved hyperglycemia and hyperinsulinemia. We suggest that the development of brain specific SIRT1 activators may exert similar effects and therefore represent a new strategy in the fight against type 2 diabetes mellitus," the authors write.

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