Create Account | Sign In: Author or Forum

Search Symptoms

Category: Pharmacy | Pulmonology | Conference News

Back to Journal Articles

Nintedanib Slows Fibrosing Interstitial Lung Disease

Last Updated: September 30, 2019.

For patients with progressive fibrosing interstitial lung diseases, nintedanib is associated with a lower rate of decline in forced vital capacity compared with placebo, according to a study published online Sept. 29 in the New England Journal of Medicine to coincide with the European Respiratory Society International Congress 2019, held from Sept. 28 to Oct. 2 in Madrid.

MONDAY, Sept. 30, 2019 (HealthDay News) -- For patients with progressive fibrosing interstitial lung diseases, nintedanib is associated with a lower rate of decline in forced vital capacity (FVC) compared with placebo, according to a study published online Sept. 29 in the New England Journal of Medicine to coincide with the European Respiratory Society International Congress 2019, held from Sept. 28 to Oct. 2 in Madrid.

Kevin R. Flaherty, M.D., from the University of Michigan in Ann Arbor, and colleagues conducted a double-blind phase 3 trial in 15 countries involving patients with fibrosing lung disease affecting more than 10 percent of lung volume on high-resolution computed tomography. Participants were randomly assigned to receive either nintedanib (150 mg twice daily) or placebo; 663 patients were treated.

The researchers found that the adjusted rate of decline in the FVC was −80.8 and −187.8 mL/year with nintedanib and placebo, respectively (between-group difference, 107.0 mL/year). In patients with a usual interstitial pneumonia-like pattern of fibrosis, the adjusted rate of FVC decline was −82.9 and −211.1 mL/year, respectively (between-group difference, 128.2 mL/year). The most common adverse event was diarrhea, which was reported in 66.9 and 23.9 percent of patients treated with nintedanib and placebo, respectively.

"We found that patients who received nintedanib had a slower rate of progression of interstitial lung disease than those who received placebo," the authors write. "This change in physiological outcomes was not accompanied by meaningful changes in measures of quality of life."

The study was funded by Boehringer Ingelheim, the manufacturer of nintedanib.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
More Information


Previous: Sports Specialization Ups Injury Risk, Especially in Girls Next: Nivolumab Therapy Prolongs Survival in Advanced Melanoma

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion: