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Efficacy of Glyburide for Gestational Diabetes Studied

Last Updated: December 30, 2009.

In women with gestational diabetes, glyburide is more effective than metformin for achieving glycemic control, according to a study in the January issue of Obstetrics & Gynecology.

WEDNESDAY, Dec. 30 (HealthDay News) -- In women with gestational diabetes, glyburide is more effective than metformin for achieving glycemic control, according to a study in the January issue of Obstetrics & Gynecology.

Lisa E. Moore, M.D., and colleagues from the University of New Mexico School of Medicine in Albuquerque randomly assigned 149 women with gestational diabetes that could not be resolved through diet to treatment with metformin or glyburide.

The researchers found that significantly more patients in the metformin group were unable to achieve glycemic control and required insulin therapy (34.7 versus 16.2 percent). The metformin group also had more non-elective cesarean deliveries and smaller birth weights. However, among patients who achieved glycemic control, the mean fasting and two-hour postprandial blood glucose levels were similar in both groups.

"In this study, the failure rate of metformin was 2.1 times higher than the failure rate of glyburide when used in the management of gestational diabetes," Moore and colleagues conclude.

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