Create Account | Sign In: Author or Forum

Search Symptoms

Category: Endocrinology | Family Medicine | Internal Medicine | Nursing | Pharmacy | Conference News

Back to Journal Articles

ENDO: Glycemic Control Good for Regular Human Insulin With V-Go

Last Updated: April 01, 2020.

For patients with type 2 diabetes, glycemic control is similar with use of regular human insulin and rapid-acting insulin when delivered with a wearable insulin delivery device, V-Go, according to a study presented at the virtual meeting of The Endocrine Society, held from March 28 to 31.

WEDNESDAY, April 1, 2020 (HealthDay News) -- For patients with type 2 diabetes (T2D), glycemic control is similar with use of regular human insulin (RHI) and rapid-acting insulin (RAI) when delivered with a wearable insulin delivery device, V-Go, according to a study presented at the virtual meeting of The Endocrine Society, held from March 28 to 31.

Pablo Mora, M.D., from the Dallas Diabetes Research Center, and colleagues conducted a noninferiority study in a population with T2D to compare the efficacy and safety of RAI versus RHI when delivered by V-Go. Data were assessed from 113 patients, including 59 with RHI and 54 with RAI.

The researchers found that the mean change in hemoglobin A1c was −0.60 percent from a baseline of 8.41 percent with RHI versus −0.38 percent from a baseline of 8.33 percent with RAI (estimated treatment difference [ETD], −0.22 percent; 95 percent confidence interval, −0.67 to 0.22 percent; noninferiority margin < 0.4 percent and P = 0.007). The mean change in total daily dose was 0.8 U/day from a baseline of 61.0 U/day with RHI versus 1.8 U/day from a baseline of 61.3 U/day with RAI (ETD, −1.04 U/day; 95 percent confidence interval, −3.18 to 1.11 U/day; P = 0.92). From prerandomization to postrandomization, the absolute change in percent of patients reporting hypoglycemia was +5.08 and +5.56 percent with RHI and RAI, respectively (ETD, −0.48 percent; 95 percent confidence interval, −10.6 to 9.1 percent; P = 0.91).

"Use of RHI with V-Go expands the affordability of insulin therapy," a coauthor said in a statement.

One author disclosed financial ties to Valeritas, the manufacturer the V-Go device.

Press Release
More Information


Previous: March 2020 Briefing - Pharmacy Next: Low Vitamin D May Reduce Mobility After Hip Fracture Surgery

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion: