Create Account | Sign In: Author or Forum

Search Symptoms

Category: Cardiology | Infections | Internal Medicine | Critical Care | Emergency Medicine | Nursing | Oncology | Pharmacy | Pulmonology | Institutional

Back to Journal Articles

NIH Launches Clinical Trials of Antithrombotics for COVID-19

Last Updated: September 14, 2020.

Two of three planned adaptive phase 3 clinical trials evaluating the safety and effectiveness of varying types of blood thinners to treat adults diagnosed with COVID-19 have launched, according to an announcement by the National Institutes of Health.

MONDAY, Sept. 14, 2020 (HealthDay News) -- Two of three planned adaptive phase 3 clinical trials evaluating the safety and effectiveness of varying types of blood thinners to treat adults diagnosed with COVID-19 have launched, according to an announcement by the National Institutes of Health (NIH).

The two current trials under the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV-4) Antithrombotics initiative will occur at more than 100 sites around the world and will involve patients who have not been hospitalized and those currently hospitalized. A third trial will soon start focusing on patients discharged after hospitalization for moderate-to-severe disease.

The adaptive protocol design allows different blood thinners to be started, stopped, or combined in response to emerging trial data. The ACTIV-4 Antithrombotics Inpatient trial will study the safety and effectiveness of low or high doses of heparin to prevent clotting events and improve outcomes in hospitalized COVID-19 patients. The ACTIV-4 Antithrombotics Outpatient trial will investigate whether anticoagulants or antithrombotic therapy (placebo, aspirin, or a low or therapeutic dose of apixaban) can reduce life-threatening cardiovascular or pulmonary complications in newly diagnosed COVID-19 patients not requiring hospital admission. Researchers will also collect patient data and blood samples to identify potential drug targets and biomarkers associated with the risk for developing COVID-19 complications.

"There is currently no standard of care for anticoagulation in hospitalized COVID-19 patients, and there is a desperate need for clinical evidence to guide practice," NIH Director Francis S. Collins, M.D., Ph.D., said in a statement. "Conducting trials using multiple existing networks of research sites provides the scale and speed that will get us answers faster."

More Information


Previous: BP Control Down in the United States From 2013-2014 to 2017-2018 Next: Coronary Artery Calcium Score IDs Coronary Heart Disease Risk

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion: