- Crohn's disease: this is a disease that affects any part of the gut and involves all the different layers of the bowel wall.
- Ulcerative colitis: which is a disease that affects the large bowel (colon) primarily and its lesions involve only the surface of the bowel wall (superficial mucosal inflammation).
Table 1: Summarizing the main differences between these two diseases
Ulcerative "procto" - Colitis
|Ulcerative hence superficial||deep (transmural)|
|Superficial hence crypt abscesses & pseudopolyps||Deep with lymphocytic infiltrate|
|No skip lesions||Skip lesions hence cobble stone appearance|
|Starts at the rectum then involves the colon||Most commonly found in the terminal ileum. Can affect any area from mouth to anus.|
|Rectal involvement hence dysentery is most common presentation|
|Risk of cancer|