Create Account | Sign In: Author or Forum

Search Symptoms

Category: Hematology

Back to Medical Reference

Drug induced hemolytic anemia overview

Published: July 16, 2009. Updated: August 09, 2009

Drug induced hemolytic anemia occurs when certain drugs interact with the red blood cell membrane, causing the cell to become antigenic.

Drugs known to cause this condition inlcude:

  • Alpha-Methyl dopa type: levodopa, methyldopa.
  • Hapten type: Penicillins, cephalosporins.
  • Quinidine type: quinidine.
  • Others: mefenamic acid, salicylic acid, sulfonamides, Thiazide diuretics, antazoline, chlorpromazine, isoniazid, streptomycin, and Motrin. Drug-induced hemolytic anemia is most often associated with G6PD deficiency.

Clinical suspicion

Once the diagnosis of hemolytic anemia is established drug intake must be excluded.

Diagnosis

Coomb test differentiates the 3 main pathologic types.

alpha-Methyl dopa type: Coomb test is positive for IgG.

Hapten type: The diagnosis can be established by incubating the patient's serum with donor erythrocytes pre-incubated with penicillin. Deposition of IgG antibody will occur only in the presence of penicillin and can be detected with the Coombs' test.

Quinidine type: The diagnosis can be established in vitro by examining deposition of complement (C3) on donor erythrocytes by patient serum, which occurs only in the presence of the drug. The Coombs' test is used to detect complement deposition on the erythrocyte surface.


Previous: Cold agglutinin disease Next: Hereditary Elliptocytosis

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

Submit the word you see below: